Meta Analysis Of The Effect Of SGLT2 Inhibitor On Oxidative Stress In Overweight Or Obese Type 2 Diabetic Patients

Objective: To evaluate systematically the effect of SGLT-2 inhibitor on oxidative stress in overweight or obese patients with type 2 diabetes mellitus(T2DM).Method: In this research,"type 2 diabetes mellitus","SGLT-2 inhibitor","oxidative stress",and "Obesity","Overweight" were searched on official websites such as EMBASE,Pubmed,Cochrane Library and CNKI.According to the criteria of inclusion and exclusion,Literature related to this study was selected,Obtain the required data and evaluate the quality by reading the literature.the Meta-analysis was carried out with Review Manager 5.3 software.intervening measure: The experimental group was given SGLT2 inhibitor intervention,while the control group was given placebo or other intervention.The observation indexes were: HbA1 c,FPG,body weight,blood pressure,SOD,MDA,Hypoglycemic event,Genitourinary infection.The systematic review finally included 11 RCTs with a total of 2075 patients,Results were obtained through meta-analysis.Results: Compared with the control group,SGLT-2 inhibitor group can significantly reduce fasting blood glucose [WMD=-1.58,95%CI [-1.91,-1.26],P<0.00001] and glycated hemoglobin(HbA1c)[WMD=–0.73,95%CI(–0.87,–0.58),P<0.00001],SGLT-2 inhibitor group can significantly reduce body weigh,which is better than the control group(WMD=-1.50,95%CI[-1.64,-1.35],P<0.00001);In terms of oxidative stress index detection,Compared with the control group,SGLT-2 inhibitor group significantly reduced MDA(WMD=-0.92,95%CI(-1.61,-0.24),P=0.008)and rise SOD(WMD=9.43,95%CI(WMD=9.43,95%CI(3.29,15.56),P=0.003);SGLT-2inhibitor group significantly reduced SBP,better than the control group(WMD =-3.04,95%CI(-3.35,-2.72),P<0.00001);The changes in DBP were also better than those in the control group(WMD=-1.25,95%CI(-1.45,-1.06),P<0.00001);In terms of adverse reactions,There was no significant difference in risk of hypoglycemia between the two groups(RR=1.30,95%CI(0.94,1.78),P=0.11).But infections of the reproductive system were more common than in the control group(RR=3.83,95%CI(2.01,7.28),P<0.00001)Conclusion: The sglt-2 inhibitor group was better than the control group inimproving blood glucose,weight loss and oxidative stress in overweight or obese patients with type 2 diabetes,SGLT-2 inhibitor also showed significant efficacy in other related risk factors such as hypertension.Therefore,sglt-2 inhibitors provide a new drug option for patients with type 2 diabetes,especially those who are overweight or obese.