Early Screening And Diagnosis Of Parkinson’s Disease In Elderly Population In Jiangxi Province

Objective:To investigate the prevalence and risk factors of Parkinson’s disease(PD)in high-risk population,prodromal PD and PD.Methods:A multi-stage stratified cluster random sampling method was used to conduct a survey of residents over 65 years old in 4 cities of Jiangxi province(Nanchang,Ganzhou,Yingtan and Jiujiang)from September 2017 to October 2019.Questionnaire includes general information(gender,age,etc.);The high-risk population of PD were screened by using the international general questionnaire of PD;The population of prodromal PD was screened according to the MDS Research Criteria for Prodromal Parkinson’s Disease;Then,PD specialists identified the patients who meet the clinical diagnosis of PD in high-risk groups one by one,and calculated their prevalence and analyzed their related risk factors.Results:A total of 3,855 pieces of complete data were collected,among them,319high-risk groups were screened(8.27%),including 65-69 years old(64 cases,4.85%),70-74 years old(57 cases,7.47%),75-79 years old(67 cases,10.39%)and 80 years old and over(131 cases,11.61%),as the growth of the age,the incidence of high-risk groups showed a trend of growing;At the same time,83 patients(2.65%)with prodromal PD were screened,The highest incidence of daytime sleepiness was89.16% in the prodromal period;Finally,68 PD patients were diagnosed(1.76%),including 40 males and 28 females,with statistically significant differences(2=7.915P=0.005).Single factors analysis showed that age,family history,history of pesticide exposure and organic solvent exposure were related to the occurrence of PD.Multivariate logistic regression analysis showed that age,family history and history of pesticide exposure were independent of other confounders as possible risk factors for Parkinson’s disease.Conclusion:The population with high-risk of PD over 65 years old in Jiangxi province is up to 8.27% and increases with age;PD precursors(≥65 years old)accounted for 2.65%;The prevalence of PD was 1.76%.Age,family history and pesticide exposure were risk factors for PD.