| Objective:Cardiovascular disease(CVD)is currently the leading threat to human health.Coronary heart disease(CHD)is the most common clinical type.Cardiovascular disease risk prediction tools can help identify high-risk groups in a timely manner,early prevention,early diagnosis,early treatment,and help build an effective three-level preventive health management model.Traditional Chinese medicine diagnosis and treatment of coronary heart disease is unique.However,there is currently shortage of coronary heart disease risk prediction tools with Chinese medicine characteristics.This study aims to non-invasively predict and evaluate the risk of coronary heart disease through the four-information information detection method of TCM,and provide reference indicators with characteristics of traditional Chinese medicine for early screening and intervention of high-risk patients with coronary heart disease,and conduct early exploration and research for follow-up Continue to study to lay the foundation.METHODS:A total of 320 patients with non-coronary heart disease and 413 patients with coronary heart disease were enrolled in four reports:tongue,voice,consultation,and pulse diagnosis.According to the Framingham Cardiovascular Risk Score(see Appendix V for a decade of heart disease in Framingham).The scores were divided into the Framingham 10-year coronary heart disease risk-risk group(=244),the intermediate-risk group(=60),and the high-risk group(=16).The Framingham 10-year coronary heart disease risk-risk group,intermediate risk The difference of tongue,elephant,heart and pulse diagnosis parameters of group,high-risk group and coronary heart disease group was analyzed.The frequency distribution of four groups of TCM consultation symptoms was analyzed.Ten-year risk of low risk group of coronary heart disease→middle-risk group→high-risk group→coronary heart disease The TCM syndrome evolution law of the group;using the decision tree C5,CHAID,C&R algorithm to establish a predictive model of coronary heart disease risk based on the four diagnostic information of Chinese medicine.RESULTS:(1)Comparison of tongue-like parameters of 216 cases of low-risk group,55 middle-risk group,15 low-risk group and 240 cases of coronary heart disease in Framingham’s ten-year coronary heart disease risk:1 overall low-risk group tongue color G,B and S values were statistically different from those in the coronary heart disease group.The G and B values of the overall tongue color of the coronary heart disease group were higher than those of the low risk group(P<0.05),and the S value was lower than the low risk group(P<0.05).The G and S values of the overall tongue color of the middle-risk group were statistically different from those of the low-risk group.The G color of the overall tongue color of the middle-risk group was higher than that of the low-risk group,and the S value was lower than the low-risk group(P<0.05).2 The R,S and V values of tongue color in the tongue of the low-risk group were significantly different from those in the coronary heart disease group(P<0.05).The R,S and V values of tongue color in the tongue root of the coronary heart disease group were lower than those in the low risk group(P<0.05).The color of the tongue in the tongue of the middle-risk group was lower than that in the low-risk group(P<0.05).In the coronary heart disease group,the tongue color H of the tongue was higher than that of the moderate risk group(P<0.05).3 The G,B,and S values of the tongue color in the middle part of the low-risk group were significantly different from those in the coronary heart disease group(P<0.05).The G and B values of the tongue color in the middle part of the coronary heart disease group were higher than those in the low-risk group.P<0.05),the color of the tongue color in the middle of the tongue was lower than that in the low-risk group(P<0.05).The G and S values of the tongue color in the middle-risk group were significantly different from those in the low-risk group(P<0.05).<0.05),the G color value of the tongue color in the middle part of the middle-risk group was higher than that in the low-risk group(P<0.05).The color of the tongue color in the middle part of the middle-risk group was lower than that in the low-risk group(P<0.05).The G,B,and S values of the tongue color of the low-risk group were significantly different from those of the coronary heart disease group(P<0.05).The G and B values of the tongue color of the tongue and heart disease group were higher than those of the low-risk group(P<0.05).The S color of tongue color in the coronary heart disease group was lower than that in the low risk group(P<0.05);the R and V values of the tongue color of the middle finger group were lower than those in the low risk group(P<0.05);the tongue tongue of the coronary heart disease group The R value of the quality color was higher than that of the intermediate risk group(P<0.05).The G,B,and S values of the left tongue color of the low-risk group were significantly different from those of the coronary heart disease group(P<0.05).The G and B values of the tongue color on the left side of the tongue-to-heart group were higher than those of the low-risk group.P<0.05),the S color of the tongue color of the left tongue of the coronary heart disease group was lower than that of the low risk group(P<0.05).The S color of the left tongue color of the middle-risk group was lower than that of the low-risk group(P<0.05).The G,B,and S values of the right tongue color of the low-risk group were significantly different from those of the coronary heart disease group(P<0.05).The G and B values of the tongue color on the right side of the coronary heart disease group were higher than those of the low-risk group(P<0.05).<0.05),the S color of the right tongue color of the tongue and heart disease group was lower than that of the low risk group(P<0.05);the S color of the right tongue color of the middle risk group was lower than the low risk group(P<0.05).The R,S and V values of the overall tongue coating color of the coronary heart disease group were lower than those of the low-risk group(P<0.05).The color G of the tongue coating color of the middle-risk group was higher than that of the low-risk group(P<0.05).The color S value was lower than the low-risk group(P<0.05);the color of the tongue coating in the coronary heart disease group was lower than that in the middle-risk group.The R and V values of tongue coating in the root of the coronary heart disease group were lower than those in the low,middle and high risk groups(P<0.05).The color of B and H in the tongue root of the coronary heart disease group were lower than those in the low risk group(P<0.05).In the coronary heart disease group and the middle-risk group,the color of the tongue coating was lower than that of the low-risk group(P<0.05).The color of the tongue coating in the middle part of the coronary heart disease group was higher than that in the high-risk group(P<0.05).The color G value of the middle tongue coating was higher than that of the low risk group(P<0.05).In the high-risk group,the G value of the tongue-tipped tongue was lower than that of the middle-risk group(P<0.05).The G-value of the tongue-tipped tongue coating in the coronary heart disease group was higher than that in the high-risk group(P<0.05).The S-value of the tongue-tipped tongue coating in the coronary heart disease group was lower than that in the low-risk group.(P<0.05).The G,B,and V values of the tongue coating on the left tongue of the coronary heart disease group were higher than those of the low-risk group(P<0.05).The R,G,B,and V values of the tongue coating on the left side of the middle-risk group were higher than those of the low-risk group(P<0.05).The S color of the tongue coating on the left side of the tongue in the middle-risk group and the coronary heart disease group was lower than that in the low-risk group(P<0.05).The G and B values of the tongue coating on the right side of the middle-risk group were higher than those in the low-risk group(P<0.05).The G color of the tongue coating on the right side of the coronary heart disease group was higher than that in the low-risk group(P<0.05).The middle-risk group and the coronary heart disease group The color of the tongue coating on the right side was lower than that in the low-risk group(P<0.05).(2)Comparison of the sound diagnosis parameters of 221 cases of low-risk group,53 middle-risk group,14 high-risk group and 197 cases of coronary heart disease in Framingham’s ten-year coronary heart disease:the sound diagnosis parameters of the coronary heart disease group were F0,F1,F2 and B4 In the middle-risk group(P<0.05);the F0 and F1 parameters of the middle-risk group were lower than the low-risk group(P<0.05);the F4 of the coronary heart disease group was higher than the low-risk group(P<0.05).(3)Framingham’s risk of coronary heart disease in 236 cases of low-risk group,58 cases of intermediate-risk group,16 cases of high-risk group and 413 cases of coronary heart disease group.Frequency distribution and syndromes:1 The top 10 symptoms of low-risk group were waist Knee soreness,low back pain,dry mouth and thirst,dizziness/dizziness,difficulty falling asleep,spontaneous sweating,chills,headache,bitterness,sleep and not easy to wake up;the top 10 symptoms in the middle-risk group are soft waist and low back pain,Dry mouth,thirst,dizziness,dizziness,bitterness,itchy skin,palpitations/sputum,dry throat,pharyngeal discomfort,forgetfulness;the top 10 symptoms in high-risk group are soft waist and knee,vision loss,whitening/early detachment,dizziness Dizziness,palpitations,cramps,low back pain,sleep,not easy to wake up,night sweats,easy to catch cold;the first 10 symptoms of coronary heart disease are chest tightness,dry mouth and thirst,palpitations,weak waist and knees,chest pain,dizziness/dizziness,low back pain,Bitter,difficult to sleep,numb hands and feet.2 Low-risk group→medium-risk group→high-risk group,the proportion of false and real syndromes increased gradually.In the high-risk group,there are yin deficiency syndrome and phlegm heat syndrome,yin deficiency and yang syndrome,qi deficiency and phlegm dampness syndrome,qi and yin deficiency and dampness heat syndrome.In the high-risk group,there were syndromes of dampness and blood stasis,while in the low-risk group and the middle-risk group,only a single dampness syndrome or blood stasis syndrome was seen.In the high-risk group,the syndrome of deficiency of qi and yin,yang deficiency and blood deficiency syndrome appeared,while in the low-risk group and the intermediate-risk group,only a single qi deficiency syndrome,yang deficiency syndrome,and blood deficiency syndrome were observed.(4)Comparison of pulse parameters of 179 cases of Framingham’s ten-year coronary heart disease,45 cases of middle-risk group,13 cases of high-risk group and 346 cases of coronary heart disease:the pulse parameters h4/hl and t1/t of coronary heart disease group were lower than low-risk group,middle-risk group,high-risk group(P<0.05);coronary heart disease group pulse parameters h5/hl,t4/t,t5/t4,t1/t4,wl/t were lower than low-risk group(P<0.05);coronary heart disease The group pulse parameters h5/hl and wl/t were lower than those in the middle-risk group(P<0.05).The pulse parameters As/Ad in the coronary heart disease group were higher than those in the low-risk group(P<0.05).The pulse parameters t1/t4 in the coronary heart disease group were lower than that in the coronary heart disease group.High risk group(P<0.05).(5)Based on the basic data of 320 medical examination patients and 413 patients with coronary heart disease and the information of four diagnoses of traditional Chinese medicine,three decision tree algorithms such as C5.0,CHAID and C&R were used to establish low-risk,intermediate-risk,high-risk and coronary heart disease groups.For the classification diagnosis model,the classification accuracy rates were 91.717%,90.909%,and 87.071%,respectively.Conclusions:(1)There are differences in information parameters such as tongue diagnosis,sound diagnosis,consultation,pulse diagnosis,etc.in the low-risk group,middle-risk group,high-risk group and coronary heart disease patients with ten-year risk of coronary heart disease,reflecting the objective information of the four diagnoses of TCM.There is a certain reference value in the prediction of the risk of coronary heart disease.(2)The predictive model of coronary heart disease risk based on the four diagnostic information of Chinese medicine has a higher prediction accuracy rate for the four diagnoses.The four diagnostic information of Chinese medicine has a certain supporting role in establishing a predictive model for the risk of coronary heart disease. |
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