Excitation Of The Right Dorsolateral Prefrontal Cortex With Transcranial Direct Current Stimulation Influences Response Inhibition And Cognitive Flexibility

Objectives: Response inhibition is a cognitive process required to cancel an intended movement and can protect from danger.Cognitive flexibility is a vitial ability that can switch between different concepts,and it can help huaman to think about multiple concepts at the same instant.Functional magnetic resonance imaging(FMRI)studies showed that the dorsolateral prefrontal cortex(dlPFC)is a crucial brain region for response inhibition and cognitive flexibility.Repetitive transcranial magnetic stimulation(rTMS)is a technique that can determine the contribution of specific cortical regions to behavior.Previous studies have found that repetitive transcranial magnetic stimulation of the dl PFC affects response inhibition and cognitive flexibility.In the current study,we used transcranial direct current stimulation(tDCS),a non-invasive,painless brain stimulation technique with no known side effects,to alter neuronal excitability.A number of tDCS studies have suggested that tDCS may affect response inhibition and cognitive flexibility.However,to date,limited work has been done to explore whether t DCS over the right dlPFC could alter response inhibition or cognitive flexibility.Therefore,this study aimed to investigate the anodal stimulus effect of tDCS on response inhibition and cognitive flexibility.We hypothesized that exciting the neural activity of the right dlPFC with anodal tDCS would enhance the ability of response inhibition and cognitive flexibility.Method: A total of 38 healthy subjects(16 males,22 females)participated in this within-subjects study.Stop-signal task(SST)and task switching were established with E-prime software.Participants received both active and sham stimulation on separatedays.SST was used to measure the participants' capacity for response inhibition.Task switching was used to measure the participants' ability of cognitive flexibility.In the active stimulation condition,we delivered a 1.5 mA direct current for 25 min(fade-in/fade-out time: 8 s);in the sham condition,we delivered a 1.5 mA direct current for 30 s at the beginning and 30 s at the end of the stimulation time.Anodal and cathodal stimulation electrodes were placed on F4 and FP1,respectively.Participants completed the SST,task switching,Stroop color-word matching task,Verbal Fluency test,and Digit Span test before and after the stimulation.Results: We first calculated the mean reaction time(RT)in the go trials and stop-signal delay(SST)and reaction time and accuracy(task switching)for each participant using ANALYZE-IT software.To calculate the individual stop-signal reaction time(SSRT),ANALYZE-IT first computes the mean RTs for all trials without a stop signal and then subtracts the mean stop-signal delay from this value.We performed a series of paired samples t-tests to compare the SSRT and RT and acc of each experimental condition with the SSRT and RT and acc of the sham and active conditions.There were no significant differences in SSRT pre-stimulation in sham or active stimulations,indicating equal response inhibition capacity among the participants.Interestingly,the difference in SSRT before and after stimulation was statistically significant in the active condition(t(33)=-2.25,p < 0.05)(Cohens d: 0.38).There were no significant differences in RT and acc pre-stimulation in sham or active stimulations.This demonstrates that participants who received anodal stimulation over the right dlPFC had significantly reduced SSRT change scores on the SST compared to participants in the sham condition.But there were no difference in task switching before and after stimulation.Conclusion: This study demonstrated that transcranial electrical stimulation of the right dlPFC can regulate response inhibition,in that anodal stimulation improvedparticipants' response inhibition.We confirm previous work suggesting that the right dlPFC is an important brain region of response inhibition.