Study On The Biomimetic Asymmetric Transamination Of ?-trifluoromethyl Ketone Catalyzed By Chiral Biarylpyridoxamine

Chiral trifluoromethylamines are important organic compounds,Which are widely in medicinal chemistry,pesticide chemistry,and material chemistry.Therefore,the development of new methods for the synthesis of chiral trifluoromethylamines is of great importance and practically useful.Transamination is an important way to synthesize chiral amines in biological systems.The process is catalyzed of by transaminases.The catalytic center of a transaminase is vitamin B₆,which is a family of pyridoxal,pyridoxamine,and their's phosphoric acid derivatives.Chiral pyridoxal/pyridoxamine catalyzed the asymmetric transamination of carbonyl compounds provides a efficient method for the synthesis of chiral amines.In this thesis,a series of axially chiral biaryl pyridoxamine/pyridoxal catalysts were developed for asymmetric biomimetic transamination of?-trifluoromethyl ketone,to give a series of chiral trifluoromethylamines in good yields with excellent enantionselectivity under mild conditions.The research includes:?1?Design and synthesis of a variety of chiral pyridoxamine/pyridoxal catalysts with biaryl skeleton.?2?Optimization of the reaction conditions for the biomimetic asymmetric transamination under the optimimal conditions.?3?Screening the substrate scope for the synthesis of a series of chiral trifluoromethylamines under the optimal conditions.