| Objective:The aim of our retrospective study is to compare the characteristics of serous borderline ovarian tumor and mucous borderline ovarian tumor.We hope to find the difference characteristics of preoperative diagnosis using tumor markers and gynecology B ultrasound between borderline ovarian tumor and benign ovarian tumor.Also we try to determine these high risk factors causing recurrence of borderline ovarian tumor.Methods:During January 1,2012 to June 30,2016,Fifty-seven borderline ovarian tumor patients were selected as borderline ovarian tumor group according their pathologic findings from Shanghai Jiaotong University,School of medicine affiliated Ruijin Hospital.They were divided into serous group and mucus group.Meanwhile,one hundred thirty-six patients were selected as benign ovarian tumor group with pathological indications of benign ovarian tumor at the same term.The patients were ruled out if their pathologic findings of ovarian endometriosis.The clinical data were including patients’ name,age,gynecology B ultrasound and tumor markers.Operation method and clinical staging,pathological pattern and postoperative therapeutic protocol were recorded from the electronic medical database.The patients’ follow-up data were received every three months.The chi-squared test and rank-sum test were applied to compare characteristics between serous and mucous borderline ovarian tumor.The implement differential analysis was applied on the tumor marker and gynecology B ultrasound in the borderline and benign ovarian tumor group.Finally,the prognosis related influencing factors of borderline ovarian tumor was analyzed.The recurrent rate was estimated by using SAS+R and Gray’s single factor analysis.The compare distributions of recurrent rate curves were received in various groups.The multi-factor analysis carried out based on COX regression model.The P value which lower than 0.05 indicated statistical significance in difference.Results:1.Onset age distribution was 20-85.The average onset age was(46.91 ± 19.08).The median age was 47.28 cases(49.12%)of patients were younger than 47 and 29 cases(50.88%)of patients were older than 47;2.The average onset age of serous borderline ovarian tumor(SBOT)was(34.00 ±12.04)years old while the average onset age of mucous borderline ovarian tumor(MBOT)was(56.50 ± 20.21)years old,which was statistically significant by rank-sum test(P=0.008).3.The maximum diameters of serous tumor and mucous tumor on average were(10.03±6.41)cm and(13.51±9.19)cm separately,which was statistically significant by rank-sum test(P=0.022).4.The positive rate of CA125 was 47.41% on the borderline ovarian tumor(BOT).Individually,the SBOT was 64.50% and MBOT was 26.92%,which was statistically significant by chi-squared test(P=0.010).5.B ultrasound positive finding was blood stream signal in lump on the BOT between the SBOT was 70.97% and MBOT was 38.46%,which was statistically significant by chi-squared test(P=0.280).Another ultrasound positive finding was papillary pattern on the BOT between the SBOT was 58.06% and MBOT was 19.23%,which was statistically significant by chi-squared test(P=0.007).And the other ultrasound positive finding was multilocular cyst on the BOT between the SBOT was 9.68% and MBOT was 65.38%,which was statistically significant by chi-squared test(P < 0.001).The last ultrasound positive finding was ground-glass echogenicity inside lump on the BOT between the SBOT was 67.74% and MBOT was 26.92%,which was statistically significant by chi-squared test(P=0.005).6.B ultrasound positive finding was blood stream signal in lump between the BOT was 56.14% and benign ovarian tumor was 13.97%,which was statistically significant by chi-squared test(P<0.001).Another ultrasound positive finding was papillary pattern between the BOT was 40.35% and benign ovarian tumor was 14.71%,which was statistically significant by chi-squared test(P <0.001).7.The single factor analysis by Gray’s test indicated that the micro-invasion was the relevant factor which does affect the recurrence of the BOT.8.The multi-factor regression analysis indicated that the factors as micro-invasion,age,clinical staging and the extent of operation were the relevant factors affecting the recurrence of the BOT.Conclusion:1.The BOT mostly strikes women in child-bearing period.2.The onset age of the SBOT is earlier than that of the MBOT.3.The size of the SBOT is smaller than that of the MBOT.4.The positive rate of CA125 of the SBOT is higher than that of the MBOT.5.The B ultrasound of the SBOT relative to the MBOT shows the following characteristics: more positive finding in blood stream signals,papillary pattern and ground-glass echogenicity;less positive finding in multilocular cyst.6.The B ultrasound of the BOT relative to the benign ovarian tumor shows the following characteristics: more positive finding in blood stream signals and papillary pattern.7.The prognosis of the BOT is related to multi-factors,among which micro-invasion is the high risk recurrence factor.In addition,the age,clinical staging and the extent of operation are also related to the recurrence of the BOT.8.The factors including tumor size,peritoneal implants,postoperative therapeutic protocol and operation method do not affect the recurrence of the BOT. |
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