| Purpose: This study aims to study the constitutional types of patients with Idiopathic membranous nephropathy(IMN)in our hospital from the perspective of TCM physiology and the relationship between the different physical types and the patient’s general data,clinical relevant indicators,pathological classification,etc.The distribution of IMN,so as to explore the susceptible constitution,transmission rule and prognosis of IMN,provide new basis and ideas for the early prevention of IMN,TCM intervention,individualized treatment and delaying the progress of renal function.Material and method: Data collection and questionnaire survey were performed on 82 patients who met the inclusion criteria in the outpatient and admission treatment of Liaoning Provincial Hospital of Traditional Chinese Medicine from September 2017 to September2019.The contents mainly included general information,laboratory indicators,pathological results and staging,TCM constitution classification and judgment table.According to the results and judgment criteria,the TCM constitution types of patients were classified.SPSS22.0 was used to analyze the relationship between TCM constitution types and clinical laboratory indicators and pathological stages in patients with idiopathic membranous nephropathy.Results:1.The proportion of TCM constitution types of patients with idiopathic membranous nephropathy in this study is as follows: Qi deficiency and Yang deficiency are the main constitution types of the disease,accounting for 26.83% and 21.95%,followed by blood stasis It accounted for 13.41%,damp heat quality accounted for 12.20%,and the proportion of phlegm dampness,yin deficiency,Qi stagnation,and special endowment was small.2.In terms of gender,there was no statistically significant difference in the distribution of various types of TCM constitutions,P>0.05.3.In terms of age distribution,differences in the distribution of constitution types of various TCMs are statistically significant,P<0.05.Among them,yang deficiency and peace quality are the most common in patients at the age of 18-45 years,qi deficiency is the most common in patients at the age of 46-60 years,and yang deficiency is the most common in patients at the age of 61-75 years.4.In terms of course of disease,the differences in the distribution of constitution types of various TCMs are statistically significant,P<0.05.Damp-heat quality is the main type of physique for patients with short course(≤ 6 months).As the course of disease gradually prolongs(6-12 months and 12-36 months),patients with qi deficiency have the largest proportion.When the duration of the disease is greater than 36 months,the proportion of patients with yang deficiency is the largest.5.In terms of pathological staging,there is no statistically significant difference in the distribution of various types of TCM constitutions,P>0.05.6.In terms of body mass index,the body mass index of patients with dampness and heat quality is the highest,and the body mass index of different TCM body types is significantly different,P<0.05.7.In terms of clinical laboratory indicators,the difference in 24 h urine protein quantification of different TCM constitution types in patients with idiopathic membranous nephropathy is statistically significant,P<0.05,in which the constitution type with the largest urine protein quantity is damp heat,followed by Blood stasis.The difference in the distribution of fibrinogen among different constitution types was statistically significant,P<0.05,among which blood fibrinogen patients had the highest fibrinogen.The difference in plasma albumin of different constitution types was statistically significant,P<0.05,and the blood plasma stasis was the lowest in plasma albumin.The difference in total cholesterol of different physique types was statistically significant,P<0.05,and the highest total cholesterol level was damp heat.There was no significant difference in triglyceride,blood creatinine and urea among different types of TCM constitutions,P>0.05.Conclusion:1.The main physical types of IMN patients are qi deficiency,yang deficiency,blood stasis and damp heat.2.Qi deficiency may be related to the incidence of IMN middle-aged patients.3.Yang deficiency may be related to the incidence of IMN elderly patients and the long-term course of IMN patients.4.Blood stasis may be related to abnormal coagulation function in IMN patients.5.Damp heat may be related to the short-term disease course and obese body type of IMN patients,and to the formation of large amounts of proteinuria and dyslipidemia in IMN patients. |
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