| Object:Through the literature study of the insomnia medical records of traditional chinese herbs,the correlation between the time of insomnia and the traditional chinese herbs used by the patient is explored,the chinese herbs used are classified into the classics,the rules of their use are summarized,and the characteristics of the chinese herbs are analyzed.Methods:Using computer search the CNKI,WANFANG data,VIP,and PubMed for the chinese herbs medical records related to primary insomnia published since 1919 to July 2019,using SPSS20.0 statistical software performs frequency analysis on the collected literatures,visually analyzes the use rules of chinese herbs used in clinics,discusses the characteristics and rules of chinese herbs used at different hours of insomnia,and provides new ideas for the use of traditional chinese herbs in clinic.Results:1.This study retrieved a total of 963 articles from 1919 to 2019 according to the search plan,excluding 510 articles by reading abstracts and 139 articles by reading the full text.Finally,314 research literatures were included,and a total of 517 cases of primary insomnia were included.2.General information:Most of the insomnia cases included in this study occurred during B12 watch(21:00-23:00)and B1 watch(23:00-01:00),and relatively few insomnia occurred during B5 watch(07:00-09:00).3.Gender distribution:Among the insomnia cases included in the study,female patients with insomnia accounted for 67.0%,and male patients accounted for 33.0%.There are more women in general insomnia than men.4.Age distribution:The age of patients with insomnia included in the study is between 17-81 years old,and the average age of insomniacs is about 46 years old.Among them,the 41-60 age group has the most insomnia patients,a total of 229 cases,accounting for 44.3%of the total,followed by the 21-40 age group,a total of 188 cases,accounting for 36.4%of the total.In the age distribution of patients with insomnia at various hours,the relative seniority of the patients with B2 watch(01:00-03:00)and B3 watch(03:00-05:00)was 62.56 ± 10.24 years old and 62.00 ± 10.39 years old.DuringBl watch(23:00-01:00),the patients were relatively young,with an average of 44.72± 10.67 years old.(07:00-09:00).Insomnia in patients under the age of20 often occurs duringB1 watch(23:00-01:00).Insomnia in patients in the age of 21-40 years often occurs duringB12 watch(21:00-23:00),B1 watch(23:00-01:00),B4 watch(05:00-07:00),and B5 watch(07:00-09:00),with a polarized distribution.Insomnia in patients aged 41-60 At various times,insomnia in patients over the age of 61 is more concentrated duringB2 watch(01:00-03:00)and B3 watch(03:00-05:00).5.Chinese herbs:After excluding the use frequency of Licorice,the most frequently used chinese herbs are Spiny Jujube,Poria,White Peony,Bupleurum,Crude Dragon Bone,Polygala,Chinese Angelica,Flowery Knotweed Stem,Oyster,Coptis,Chuanxiong,they are used by 311,279,217,208,203,182,169,165,163,163,138,128 times,the utilization rates are 60.2%,54.0%,42.0%,40.2%,39.3%,35.2%,32.7%,31.9%,3 1.5%,26.7%,24.8%.And in the proportion of medications at each hour,the Spiny Jujube accounted for the largest proportion at the time of B3 watch(03:00-05:00),accounting for 66.7%,and Poria was the largest at the time of B4 watch(05:00-07:00),accounting for 51.5%,White Peony used the largest proportion duringB12 watch(21:00-23:00),accounting for 43.7%,Bupleurum was the largest used duringB12 watch(21:00-23:00),accounting for 44.5%,and the Crude Dragon Bone was used duringB2 watch(01:00-03:00),the medication accounted for the largest proportion,accounting for 39.3%.DuringB3 watch(03:00-05:00),Polygalais the largest proportion of use,accounting for 41.7%.DuringB2 watch(01:00-03:00),Chinese Angelica is the largest proportion of use,accounting for 44.3%,the Flowery Knotweed Stem are used most during B1 watch(23:00-01:00),accounting for 38.1%,and the Row Oyster Shell are used most duringB3 watch(07:00-09:00),it accounted for 41.7%,Coptis had the largest proportion of medications during the B1 watch(23:00-01:00),accounting for 33.9%,and Chuanxiong had the largest proportion of medications during the B12 watch(21:00-23:00),accounting for 27.8%.Characteristics of the frequency of medication at different time:After excluding the frequency of use of Licorice,among the insomnia cases during B12 watch(21:00-23:00),the top three most frequently used medications are Spiny Jujube,Bupleurum,White Peony,and Poria,used separately 134 times,109 times,107 times,107 times,the utilization rate was 54.7%,44.5%,43.7%,43.7%.Among the insomnia casesduring B1 watch(23:00-01:00),the top three most frequently used chinese herbs were Spiny Jujube,White Peony,Flowery Knotweed Stem,and Poria,which were used 59 times,50 times,45 times,45 times respectively The utilization rates are 50%,42.4%,38.1%,and 38.1%,respectively.Among the cases duringB2 watch(01:00-03:00),the top three most frequently used medications were Spiny Jujube,Chinese AngelicaSinensis,and Poria,which were used 34 times,27 times,and 25 times respectively,and the usage rates were 55.7%and 44.3,respectively.%,41%.Among the insomnia cases duringB3 watch(03:00-05:00),the top three most frequently used medications were Spiny Jujube,Polygala,Bupleurum,and White Peony,which were used 24 times,15 times,14 times,14 times,respectively.The rates were 66.7%,41.7%,38.9%,and 38.9%,respectively.Among the insomnia cases duringB4 watch(05:00-07:00),the top three most frequently used medications were Poria,Spiny Jujube,and Chinese Angelica,which were used 17 times,14 times,and 13 times respectively,and the usage rates were 51.5%,66.7%,and 39.4%.Among the insomnia cases duringB5 watch(07:00-09:00),the top three most frequently used medications were Spiny Jujube,Poria,and Bupleurum,which were used 14 times,12 times,and 10 times respectively,and the usage rates were 58.3%,50%,41.7%.6.Medicinal nature and flavor:Medicinal nature:During B12 watch(21:00-23:00)insomnia,the chinese herbs used were mostly cold in nature,balance in nature,and warm in nature,and the usage rates were 27.0%,23.0%,and 19.6%,respectively.During B1 watch(23:00-01:00)insomnia,the chinese herbs used were mostly cold in nature,balance in nature,and warm in nature,and the usage rates were 26.7%,25.5%,and 20.9%,respectively.During B2 watch(01:00-03:00)insomnia,the chinese herbs used were mostly cold in nature,balance in nature,and warm in nature,and the usage rates were 25.5%,24.3%,and 18.3%,respectively.DuringB3 watch(03:00-05:00)insomnia,the chinese herbs used were mostly cold in nature,balance in nature,and warm in nature,and the usage rates were 24.7%,23.0%,and 17.7%,respectively.During B4 watch(05:00-07:00)insomnia,the medications used were cold in nature,balance in nature,and warm in nature,and their usage rates were 25.0%,23.9%,and 22.2%,respectively.During B5 watch(07:00-09:00)insomnia,the chinese herbs used were mostly cold in nature,balance in nature,and warm in nature,and the usage rates were 25.3%,24.2%,and 21.9%,respectively.Medicinal flavor:During B12 watch(21:00-23:00)insomnia,the chinese herbs used were sweet in flavor,acrid in flavor,and bitter in flavor,which were used 1,481 times,970 times,and 907 times,respectively,and the usage rates were 38.8%,25.4%,and 23.7%,respectively.During B1 watch(23:00-01:00)insomnia,the chinese herbs used were sweet in flavor,acrid in flavor,and bitter in flavor.They were used 724 times,538 times,and 494 times,and the usage rates were 37.9%,28.2%,and 25.9%,respectively.During B2 watch(01:00-03:00)insomnia,the chinese herbs used were sweet in flavor,acrid in flavor,and bitter in flavor,which were used 378 times,230 times,and 230 times respectively,and the usage rates were 39.1%,23.8%,and 23.8%,respectively.DuringB3 watch(03:00-05:00)insomnia,the chinese herbs used were sweet in flavor,acrid in flavor,and bitter in flavor.They were used 224 times,148 times,and 146 times,and the usage rates were 37.7%,24.9%,and 24.6%,respectively.During B4 watch(05:00-07:00)insomnia,the chinese herbs used were sweet in flavor,bitter in flavor,and acrid in flavor,which were used 203 times,123 times,and 113 times,and the usage rates were 40.9%,25.0%,and 22.8%,respectively.During B5 watch(07:00-09:00)insomnia,the chinese herbs used were sweet in flavor,acrid in flavor,and bitter in flavor,which were used 140 times,96 times,and 82 times,respectively,and the usage rates were 38.4%,26.4%,and 12.5%,respectively.7.Meridian:The traditional chinese herbss are mostly used in liver channel,heartchannel and spleen channel,which account for 17.8%,17.6%and 14.6%of the total number of channels in all cases.In the case of insomnia in B12 watch(21:00-23:00),the traditional chinese herbss used were mostly attributed to the three channels of liver,heart and spleen,which accounted for 17.3%,15.0%and 14.5%of the total insomnia duringB12 watch(21:00-23:00)respectively.In the case of insomnia duringB1 watch(23:00-01:00),the traditional Chinese chinese herbss used are mostly attributed to the three channels of the liver,heart,and spleen,which account for 17.7%,17.6%,and 15.6%of the total insomnia duringB1 watch(23:00-01:00),respectively.In the case of insomnia during B2 watch(01:00-03:00),the traditional Chinese chinese herbs used is mostly attributed to the three channels of the liver,heart,and spleen,accounting for 18.5%,17.5%,and 16.1%of the total insomnia of the innocence,respectively.In theB3 watch(03:00-05:00)cases of insomnia,the traditional Chinese chinese herbs used is mostly attributed to the three channels of the liver,heart,and lung,accounting for 17.6%,17.2%,and 14.7%of the total insomnia duringB3 watch(03:00-05:00)respectively.In the case of insomnia duringB4 watch(05:00-07:00),most of the traditional Chinese chinese herbss used were attributed to the three channels of the liver,spleen,and heart,which accounted for 20.0%,15.2%,and 14.5%of the total insomnia at that time.In the case of insomnia duringB5 watch(07:00-09:00),the traditional Chinese chinese herbs used is mostly attributed to the three channels of the liver,spleen,and lung,accounting for 16.9%,15.7%,and 15.1%of the total insomnia duringB5 watch(07:00-09:00)respectively.In the insomnia of B12 watch(21:00-23:00),B1 watch(23:00-01:00),B2 watch(01:00-03:00)and B4 watch(05:00-07:00),the use of chinese herbs mostly belongs to the channels ofliver,heart,and spleen,in the insomnia duringB3 watch(03:00-05:00),the use of chinese herbs mostly belongs to the channels of liver,heart,and lung,in the insomnia duringB5 watch(07:00-09:00),the use of chinese herbs mostly belongs to the channels ofliver,spleen and lung.Conclusions:1.Chinese herbs used:Spiny Jujube,Poria,White Paeony,Bupleurum,Crude Dragon Bone,Polygala,Chinese Angelica,Polygni Multiflori Caulis,Oyster,Coptis,Szechuan Lovage Rhizome overall use rate is higher.The chinese herbs used in the treatment of insomnia at various times are mostly Spiny Jujube,Poria,White Paeony and other types of nourishing Yin and nourishing the nerves,and there is no obvious difference.By combining the various types of insomnia with the resulting insomnia medications,the time-related types of insomnia medications are transformed:patients with difficulty falling asleep or easy to wake up in the B12 Watch(21:00-23:00),use White Paeony,Bupleurum,Szechuan Lovage Rhizome more often;Patients who are easy to wake up in B1 Watch(23:00-01:00)use Polygni Multiflori Caulis and Coptis;patients who have difficulty falling asleep in B2 Watch(01:00-03:00),easy to wake up,and early wake up use Chinese Angelica,Crude Dragon Bone;patients who are easy to wake up or early wake up in B3 Watch(03:0-05:00),using Spiny Jujube,Oyster,Polygala;For patients who are easily awakened or early awakened when in the B4 Watch(05:00-07:00),using Poria more.2.The nature and flavor of chinese herbs:The chinese herbs used in insomnia are mostly cold in nature,balance in nature,warm in nature,and sweet in flavor,acrid in flavor,and bitter in flavor.There is no obvious difference in insomnia occurring at different times.3.Chinese herbs meridians:Most of the insomnias that occur at various times are attributed to the channels of liver,heart,and spleen,and some are slightly different at B3 watch(03:00-05:00)and B5 watch(07:00-09:00),(chinese herbs for insomnia in B3 watch(03:00-05:00)are mostly attributed to the channels of liver,heart and lung,while insomnia at B5 watch(07:00-09:00)are mostly attributed to the channels of liver,spleen and lung),but in general there is no obvious difference.4.Regarding the relationship between medication and the time:Although the medications used to treat insomnia are not very different in general,they may be related to the dysfunction of the qi and blood at a specific time when insomnia occurs(Qi and blood of spleen channel and heart channel running weak in B12 watch(21:00-23:00),B1 watch(23:00-01:00)). |
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