A synthetic approach toward novel beta-lactams

beta-lactam antibiotics which is a class by itself, covers a wide range of antibiotics that includes penicillin, pencilin derivatives, cephalosporins, carbapenems, and any antibiotic agent that contains a 2-azetidinone ring. [2] In recent past research it has been established that beta-lactams show therapeutic and anticancer activity with low toxicity.[2] It has also been reported by our lab that N-chrysenyl and N-phenanthrenyl 3-acetoxy-4-aryl-2-azetidinone can exhibit potent selective anticancer activity towards prostate, colon, pancreatic cancer and leukemia at low concentrations, all of this was revealed by means of a structure activity study.[2] The goal of our research is the synthesis of a beta-lactam that contains a hydroxy group at the one carbon spacer of the third carbon belonging to the 2-azetidinone ring system.