| During the past four decades, Solid Dispersion technology has been successfully used to increase the dissolution rate and bioavailability of poorly water soluble drugs. Recently, attempts are being made to incorporate porous materials in Solid Dispersion to increase the solubility. The main aim of this thesis is to determine the effect of Silicon Dioxide in Solid Dispersion and comparing the dissolution profiles when Silicon Dioxide is incorporated in Solid Dispersion of drug (Indomethacin), polymer (Povidone K-29/32) (Internal System) to the physical mixture of drug, polymer, Silicon Dioxide (Physical System) and Solid Dispersion of drug and polymer with Silicon Dioxide externally (External System). Three different systems with different Syloid ratios, and polymer ratio's were prepared (Drug: Polymer: Syloid: 1:1:3, 1:1:2.5, 1:2:2). All the ratio's having three systems (Internal, External, Physical) were prepared. The dissolution profiles from all the ratio's were individually evaluated and compared with respective Solid Dispersion ratios. Dissolution was significantly improved in Internal System of all the ratio's compared to External, Physical and Solid Dispersion Systems. Dissolution was improved due to presence of pores in Syloid 244FP which improves the particle size of the system and thereby increasing the dissolution rate of the newly developed Internal Solid Dispersion System. The physicochemical properties of the all the systems were studied using with DSC and X-ray diffraction. Absence of peak observed in DSC, confirms the presence of drug in amorphous form in both Internal and External Systems. X-Ray Diffraction study indicates that crystallinity was lost in Internal, External Systems of all the ratios. Both DSC, and X-Ray Diffraction (XRD) studies support that the drug is fully incorporated into Syloid and is present in an amorphous form in Internal Systems. Formation of hydrogen bond between Indomethacin and Plasdone K-29/32 was concluded by FTIR. |
