| Erectile dysfunction is the inability to sustain an erection during sexual performance and is caused by a loss of penile corporal smooth muscle cells and nitregic nerves, fibrosis, oxidative stress or from Corporal Veno-Occlusive Dysfunction (CVOD). In addition to known risk factors such as cavernosal nerve damage, diabetes or aging, impotence may arise from environmental exposure.;This thesis explores the use of MDSC and PDE5i to correct CVOD occurring in the rat after BCNR. The hypothesis is that a combination of MDSC and sildenafil would be the most effective therapy in treating cases of CVOD. This work also explores the exposure of adult rats to BPA at doses comparable to occupational exposure and suggestive of environmental risk. The hypothesis suggests BPA causes a reduction in the smooth muscle cells/ collagen ratio and induces fat accumulation in the penile corpora cavernosa, thus causing ED. |
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