The effect of diet composition on energy balance, body weight loss and gut hormone levels in rats with or without ileal transposition

Gastrointestinal bypass surgery is the most effective technique to achieve weight reduction. Ileal transposition (IT) surgery results in similar weight loss due to ileal over stimulation. This study evaluated the effects of different diets on food intake, body weight and body composition after IT or sham surgery.; Rats fed high carbohydrate (HC) diets were significantly heavier (p<0.01) than high protein (HP) and high fat (HF) diet-fed animals in IT and sham groups at the end of the study (HP and HF did not differ significantly). Initially HC rats ate more than HP and HF rats (p<0.001) but this difference disappeared after 10 days.; IT-HP rats had the least body fat at sacrifice, and the GI tract of IT-HP and IT-HF rats was larger than the IT-HC group [duodenum (p<0.001)], confirming the ileal over-stimulation caused by these diets.; HP diet appeared to be most effective in preventing fat gain after IT.