Optical geometry calibration method for computed tomography and applications of compact microbeam radiation therapy

Digital tomosynthesis is a type of limited angle tomography that allows for 3D information reconstructed from a set of X-ray projection images taken at various angles using an X-ray tube, a mechanical arm to rotate the tube, and a digital detector. Tomosynthesis reconstruction requires the knowledge of the precise location of the detector with respect to each X-ray source.;Current clinical tomosynthesis methods use a physically coupled source and detector so the geometry is always known and is always the same. This makes it impractical for mobile or field operations. We demonstrated a free form tomosynthesis and free form computed tomography (CT) with a decoupled source and detector setup that uses a novel optical method for accurate and real-time geometry calibration.;We accomplish this by using a camera to track the motion of the source relative to the detector. A checkerboard pattern is positioned on or next to the detector using an extension arm in such a way that the pattern will not move relative to the detector. A camera is mounted on the source in a way that the pattern is visible during imaging and will not move relative to the source. The image of the pattern captured by the camera is then used to determine the relative camera/pattern position and orientation by analyzing the pattern distortion. This allows for accurate, real time geometry calibration of the X-ray source relative to the detector. This method opens the doors for inexpensive upgrades to existing 2D imaging systems and an even more exciting application of a mobile, hand-held CT imaging system.