Difunctionalization Of Alkenes And Synthesis Of Heterocycles Containing Sulfur From N-(2-bromoallyl) Amines

Difunctionalization of alkenes has very important position in the synthesis of organic chemistry.Under the one-pot,each of double bonds adds a reactive group,forms new bonds.This strategy can reduce the reaction cost and simplify the experimental steps.1.A novel method synthesis of halogenated isoindoline-1,3-dione has been developed.By using DCE as solvent,difunctionalization of alkenes with NBS and N-hydroxyphthalimide led to the efficient synthesis of 2-（2-bromo-2-phenylethoxy）-isoindoline-1,3-dione.It can realize the synthesis of 2-（2-iodo-2-phenylethoxy）-isoindoline-1,3-dione with NIS instead of NBS.Under other conditions unchanged,it can afford a range of 2-（2-bromo-1-phenylethoxy）isoindoline-1,3-dione with solvent by CH₃CN.Heterocyclic compounds have been hot topics in the study of chemical.This article reported a novel Cu I-catalyzed synthesis of heterocycles containing sulfur from N-（2-bromoallyl）amines and carbon disulfide.2.A novel method for Cu I-catalyzed synthesis of 1,3-thiazolidine-2-thiones containing aryl or alkyl has been developed.The protocol provides the facile and high atomic economic synthesis of 1,3-thiazolidine-2-thiones containing aryl or alkyl using Cu I as a catalyst,K₃PO₄as base,N-（2-bromoallyl）amines and carbon disulfide as substrates.