Studies On The Transition Metals Mediated Construction Of S-N/C-N Bonds

Amine structures exist widely in the biological world and present extremely important physiological functions.Therefore,most drugs contain X-N（X=C,S）.Alkaloids,proteins,nucleic acids,antibiotics and many hormones all contain amine groups,which are complex derivatives of amines.The amination reaction has become an indispensable and important means to synthesize a series of biologically and pharmacologically active molecules.In recent years,the introduction of amines through the development of green and efficient X-N（X=C,S）bond construction methods is one of the hotspots in the field of chemical synthesis.This paper mainly summarizes the recent research progress in the construction of X-N（X=C,S）bond amination reaction,and summarizes and prospects the challenges and development prospects in this field.This paper will detail the results of our research based on amination.The thesis includes the following three parts:The first section of the paper summarizes the research achievements and progress of amine derivatives,drugs and pesticides,and the synthesis reaction methods of amine compounds.In the second section of the thesis,a simple and efficient method was devolped to synthesize arylsulfonamide compounds by constructing S-N bonds.In this method,a series of aryl sulfonamide compounds were synthesized with sulfonyl chloride compounds and aryl nitro compounds as the reaction substrates,using elemental iron as the reducing agent,and 60^oC reaction for 36 hours as the optimal conditions with a yield of up to 93%.The high yield of the target product,simple reaction,high atom utilization rate,and easy handling are the main advantages of this method,and the reaction can be prepared on a large scale.In the third section of the paper,auther explored Cu（OAc）₂/acids promoted the oxidative cleavage ofα-aminocarbonyl compounds with Amines:efficiently and selectively construct C-N and C=N bond to synthesize 2-t-Amino-2-imino-carbonyl and 2-Amino-2-oxocarbonyl.This reaction has a wide reaction range and provides a convenient way for theαfunctionalization ofα-amino ketones.According to relevant literature reports and experimental research results,this paper proposes a suitable reaction mechanism,through control experiments to verify that the oxygen in the new formed carbonyl group comes mostly from water.