| Doxorubicin(DOX)is an anthracycline broad-spectrum antitumor antibiotics.Despite being highly effective for fighting cancers,DOX is also a carcinogenic agent.Patients taking DOX of anti-cancer drugs will excrete drug residues in urine through renal metabolism.If the urine containing DOX is not handled properly,it will cause significant genotoxicity to animals,plants and humans.Urine source separation is an efficient,simple,and economical method for removing DOX from urine source.In order to achieve the urine source separation of DOX in urine,two kinds of magnetic nanomaterials:magnetic Cu3(PO4)2 nanoflowers and magnetic Fe3O4@TA-Cu2+nanoparticles were prepared in this paper,which were applied to adsorb DOX in real urine.The actual influencing factors of DOX removal efficiency and the adsorption mechanism are studied.First of all,magnetic Cu3(PO4)2 nanoflowers were prepared through anchoring amino functionalized magnetic Fe3O4 nanoparticles on the Cu3(PO4)2 nanoflowers,which were characterized and confirmed.In synthetic urine,over 95%of DOX(20mg·L-1)was removed by a little of magnetic nanoflowers(0.05 g·L-1)within 10 min.Due to the complexity of human urine,the removal rate of DOX(10 mg·L-1)in real urine,was only 29%by the magnetic Cu3(PO4)2 nanoflower(0.05 g·L-1).When the adsorption dose was increased to 1 g·L-1,the removal rate of DOX in urine reached95%.It can be seen from the above results that the chelation of Cu2+on the material and DOX can effectively remove the DOX in the urine.However,due to the large amount of Cu2+being encapsulated inside the material,the amount of Cu2+exposed on the surface of magnetic Cu3(PO4)2 nanoflowers is limited,so resulting in the Cu2+active sites can not be fully utilized.In order to solve this problem,magnetic nanoparticles(Fe3O4@TA)coated with tannic acid(TA)was prepared,and the Cu2+was loaded on the surface of the magnetic material by chelation of Cu2+and TA to obtain Fe3O4@TA-Cu2+nanoparticles,which improved the utilization rate of Cu2+.Through the experience about Fe3O4@TA-Cu2+nanoparticles to remove DOX in urine,it was found that the removal rate of DOX concentration(10 mg·L-1)in urine which can reach more than 98%by adjusting the amount of adsorbent used within 10min.The adsorption kinetics and isothermal of magnetic Cu3(PO4)2 nanoflowers and Fe3O4@TA-Cu2+nanoparticles adsorb DOX,which were best fitted the pseudo-second order model and the Freundlich isothermal adsorption model.It was shown that these two magnetic nanomaterials are heterogeneous multi-layer chemical adsorption for DOX.From the perspective of environmental protection and performance,the use of magnetic Fe3O4@TA-Cu2+nanoparticles to remove DOX in urine is an advantage.And its maximum theoretical adsorption capacity was 8.896mg·g-1.The studies showed that magnetic Fe3O4@TA-Cu2+nanoparticles can quickly and efficiently adsorb the residual drug DOX in primary urine,and the material can be separated from the reaction system simply and quickly by magnetism,which lays a good foundation for subsequent personal practical applications. |
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