Design,synthesis And Application Of Novel Organic Fluorescent Nanomaterials

In recent years,fluorophores with aggregation-induced luminescence characteristics(AIEgens)have the advantages of higher emission efficiency,excellent photostability,greater Stokes shift,and higher modifiable multi-functional flexibility,have become ideal material for fluorescent nanomaterials.In this paper,several new types of AIEgens nanoparticles were constructed,and their applications in antibacterial or cellular imaging were explored.Certain progress was made,the results are as follows:1.Using tetraphenylethylene(TPE)as the building blocks,the zinc(II)-coordinated dimethylpyridine amine(ZnDPA)unit was introduced to synthesize the cage molecule ZnDPA-TPE-Cage.The research results showed that the highly aggregated ZnDPA-TPECage not only had the ability to selectively image S.aureus,but also can efficiently produce ROS to kill S aureus effectly;2.Using TPE cage molecules,fluorescein and rhodamine B derivatives as initiators,three kinds of temperature-sensitive fluorescent polymer nanoparticles were synthesized through atom transfer radical polymerization(ATRP)reaction.By adjusting the ratio of the three components to construct a full-color luminescent nanoparticle system(including white hybrid nanoparticles,WHNs)by fluorescence resonance energy transfer(FRET)effect.WHNs have high stability,good biocompatibility and fluorescence-color temperature sensitivity,which can monitor cell temperature;3.Using a chalcone derivative with AIE properties as an initiator,a temperaturesensitive polymer was synthesized through ATRP reaction,and the end of the polymer was modified with mitochondrial-targeting triphenylphosphine to prepare polymer nanoparticles BCP-P.The experimental results of mitochondrial colocalization imaging and temperature monitoring showed that BCP-P can not only target mitochondria for imaging,but also has fluorescence-temperature sensitivity to monitor mitochondrial temperature.The novel fluorescent nanomaterial synthesized in this article has unique applications and advantages in antibacterial or cell imaging,which broadens the development of related materials in biomedical engineering.