Synthesis And Study Of 1,2,3-triazole-based Sequence-defined Oligomers

Mimicking nature to create polymers with well-defined sequence and precise chain length for multitudinous applications is an increasingly attractive but challenging field.In the absence of biological types of machinery,robust and efficient chemical reactions are important for the construction of artificial sequence-defined polymers.The 1,2,3-triazole frame obtained from the click reaction of the azide and the alkyne reaction has good stability while having structure and electron properties similar to the biological peptide bond.The 1,2,3-triazole is often used to link biological monomers to construct biomimetic polymers with biological stability.The first chapter of this thesis introduces the research background based on 1,2,3-triazole sequence-defined polymers.In chapter 2,monodisperse sequence-defined oligomers bearing chiral backbone and different side chains were designed and synthesized through two strategies,including iterative sequential growth(ISG)strategy and iterative exponential growth(IEG)strategy.In Chapter 3,dual sequence-defined polytriazoles were synthesized by thioalkynes bearing two side-chains using a one-pot strategy through ISG strategy.The above-mentioned sequence-defined oligomers were characterized by nuclear magnetic resonance(NMR),size exclusion chromatography(SEC),negative mode electrospray ionization mass(ESI-MS),matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF-MS)and tandem mass spectrometry(MS/MS).