Design And Synthesis Of Drugs For The Prevention And Treatment Of Alzheimer’s Disease

Alzheimer disease(AD)is a neurological disease with insidious onset,complex etiology,gradual and irreversible,age-related and progressively worsening over time.The current treatment is only symptomatic.Treatment of drugs and methods,but the therapeutic efficacy and results are not ideal.Given the prevalence of AD and the expected increase in incidence,developing an effective treatment is critical to public health.Due to the multifactorial pathogenesis of the disease,the treatment of multi-targeted ligands is a promising direction for the treatment of new AD drugs.The neurotoxicity caused by abnormal deposition of Aβ is still one of the current research hotspots.The production of Aβ is closely related to the three secretases of APP metabolic pathway,and the pathway mainly producing toxic Aβ40 and Aβ42 is involved in γ-secretase.However,there are few studies on the intervention of AD with important monomers and components with γ-secretase as the target.It is in its infancy,and most of the research hotspots are mainly in the selective expression and structural activity of γ-secretase,γ-secretase.It is an aspartic acid presenilin protein.Studies have suggested that some non-steroidal antiinflammatory drugs are considered to be gamma-secretase modulators(GSMs),which can selectively and effectively reduce Aβ42.And the efficacy is focused on adjusting the APP hydrolysis site but does not affect the activity and function of other related secretases.Although the mechanism of action cannot be determined,γ-secretase modulators can reduce the pathogenesis and abnormal deposition of Aβ without destroying other functions of γ-secretase,and become a target for the treatment of AD,and also represent a class of treatments that can be expected AD One direction.The development of drugs that can regulate γ-secretase and the understanding of the different mechanisms of γ-secretase in the hydrolysis pathway will bring new dawn to the prevention and treatment of AD.In this paper,the compounds which synthesize imidazolyl phenylamine with imidazolium as the active structure were synthesized,and some possible molecular design and synthesis studies were synthesized.