Several Functional MOFs Designs And Applications In Salvianic Acid A Electrochemical Sensors

Salvianic acid A（SAA）is a water-soluble phenolic acid isolated from Salvia miltiorrhiza.Its medicinal value has been studied by more and more biomedical scientists.Quantitative analysis of SAA by electrochemical methods has been extensively studied.However,the use of electrochemical technology to construct a high sensitivity and wide range of sensing detection platform for SAA needs to focus on the preparation of sensing interface modification materials with high selectivity and stable performance.In this study,metal-organic framework materials（MOFs）or their derivative composites were used to construct a highly sensitive and selective current-type electrochemical sensor for quantitative detection of SAA.1)Nanocomposite[（RGO-MWCNTs）@HKUST-1]based on HKUST-1,reduced graphene oxide（RGO）and multi-walled carbon nanotubes（MWCNTs）were prepared by green simple hydrothermal and ultrasonic method.It was found by electron microscopy that RGO supported by MWCNTs was successfully coated on the surface of HKUST-1.An electrochemical sensor using the composite material to modify the electrode for the detection of SAA was constructed.2)Pd NPs@Zn O-Co₃O₄nanocomposite were synthesized by rapid oxidation treatment of zinc-cobalt bimetallic zeolitic imidazolate framework and then in situ chemical reduction of Pd NPs on the surface of nanocrystals.After binding with MWCNTs,Pd NPs@Zn O-Co₃O₄-MWCNTs nanocomposite was formed and an enzyme-free electrochemical sensor for high sensitivity detection of SAA was constructed.3)Cu₂O-Co₃O₄polyhedral crystal material was prepared by high temperature calcination of heterobimetallic ZIF.Cu₂O-Co₃O₄-RGO-MWCNTs nanocomposite was prepared by combining RGO and MWCNTs with excellent conductivity,and modified on the surface of glassy carbon electrode to construct SAA electrochemical sensor.Under the optimal experimental conditions,the modified electrode of Cu₂O-Co₃O₄-RGO-MWCNTs showed good catalytic activity for SAA.The three SAA electrochemical sensors constructed have wide detection ranges and low detection limits.And the constructed electrochemical sensors have excellent characteristics such as good repeatability,high stability and strong anti-interference ability.In addition,successfully applied to the determination of SAA in the actual sample,the test results are satisfactory.It provides a theoretical basis for studying the redox mechanism of SAA and provides new ideas and methods for the quantitative detection of SAA.