Transition Metal-catalyzed Cross-coupling And Defluorinative Coupling Reaction Of Trifluoromethyl Compounds

Transition-metal-catalyzed cross-coupling reaction is a common method to construct chemical bonds.Trifluoromethyl group has shown unique physiological properties which is introduced into the molecule to significantly affect binding affinity,metabolic stability,lipophilicity and bioavailability.Therefore,the development of efficient transition-metalcatalyzed cross-coupling reaction of trifluoromethyl compounds has always been the focus of organic chemistry research.On the other hand,transition-metal-catalyzed defluorinative functionalization of trifluoromethyl compounds can quickly synthesis monofluorine compounds,which has attracted great attention from chemists in recent years.This paper has carried out research around these two points.The main content of this paper includes the following four parts:(1)a brief overview of the transition-metal-atalyzed cross-coupling and defluorinative functionalization reaction of trifluoromethyl compounds in recent years.(2)Using KOH as the oxygen source,the cross-coupling reaction of trifluoromethyl alkenyl chloride and KOH is realized which quickly synthesis a series of 2-trifluoromethyl benzofuran derivatives.(3)Palladium-catalyzed selective defluorinative sulfenylation under mild conditions for the synthesis of fluorovinyl thioethers has been developed.The reaction has the advantages of simple and easy-to-obtain material,wide substrate scope,higher yield,and excellent functional group compatibility.(4)A palladium-catalyzed strategy for the synthesis of monofluoroalkenes from defluorinated arylation of trifluoropropionamide has been developed.The method has mild conditions and shows excellent functional group compatibility.