Total Synthesis Of Natural Products Mornaphthoate E And Euphorlactone A

This thesis mainly studies the total synthesis of natural product methyl naphthoate-Mornaphthoate E and long-chain fatty acid lactone-Euphorlactone A.The thesis begins with an overview of the total synthesis of natural products: First,it introduces the classification of the chemical structure of medicinal natural products,including alkaloids,terpenes,flavonoids,coumarins and lignans.Then the meaning of the total synthesis of natural products is introduced-natural-source compounds play a very important role in our lives.In recent years,as the complexity and diversity of newly discovered natural molecules continue to increase,as well as the impact of rare biologically active natural products and the demand for its analogues,the field has gained a great momentum of development.In this large research context,we conducted a total synthesis study on the natural products Mornaphthoate E and Euphorlactone A.Mornaphthoate E was extracted and isolated from the roots of Mornaphthoate by our research team,and then tested in vitro for the cytotoxicity(A549,MCF-7 and MDA-MB-231)and cholinesterase(ACh E and BCh E)of three cell lines Inhibit activity.The test results showed that Mornaphthoate E exhibited growth inhibitory effects on all three types of tumor cells.At present,apart from the related separation literature,there is no other literature that reports on this molecule.Since it is the first synthesis,there is no support from the reported literature,so this paper has carried out the synthesis of bionic strategy.Through a series of reactions such as methylation,oxidation,allylation,cross metathesis of olefins,and 6πelectric cyclization,the total synthesis of the natural compound Mornaphthoate E was finally completed.Euphorlactone A was also extracted and separated from the whole Euphorbia euphorbia plant in southern Europe by our research team.Due to the very small amount allocated at that time and the impact of the new crown epidemic,the research team has not yet determined the absolute configuration of Euphorlactone A,and the molecule has changed.This requires a total synthesis study.In addition to accurately giving its absolute configuration,it can also further explore the biological activity of Euphorlactone A.Euphorlactone A is also synthesized for the first time.The molecule contains two chiral centers and four isomers.This paper intends to complete the synthesis of the parent structure through the zipper reaction,nucleophilic addition,and Sonogashira reactions of alkynes.Later,we will give an overview of the key reactions in the synthesis process,and will also analyze the difficulty and challenges of the design route in detail.