Bilayer Bionic Functional Hydrogel Built Transdermal Patch For Anticancer Drug Delivery System

The transdermal route of drug administration has the advantages of avoiding the first-pass effect of the liver,convenience,and painlessness.Hydrogels have been favored because of structures and physicochemical properties.However,the dualnetwork(DN)hydrogel with high interface toughness and high strength still has obvious defects such as single function and poor adhesion performance for transdermal drug delivery patches.Therefore,it is urgent to develop a new type of skin patch with good performance and powerful functions.The purpose of this study is to develop a universal multifunctional self-adhesive hydrogel patch,which includes a drug-loading layer and a functional layer.On this basis,doxorubicin hydrochloride(DOX)can be made to avoid severe toxic reactions Dermal patch.In order to obtain a suitable skin adhesion material,DN gels were doped with catechol derivatives of different forms,and zinc oxide nanoparticles(Zn O nps)doped DN hydrogels were introduced as functional layers to design a double-layer gel structure to improve Stability and functionality.A new transdermal preparation containing DOX as a pharmaceutical ingredient is prepared.Performance evaluation was performed by testing the release rate of DOX in vitro,and the antibacterial effects of the materials were studied using E.coli and Bacillus subtilis.The main research process is as follows:(1)Scheme optimization of mussel-doped dual-network hydrogel skin patch was carried out through mechanical,adhesion and self-healing tests.(2)Screen suitable Zn O composite hydrogel functional layers and construct a double-layer structure to obtain functional double-layer hydrogels with better performance.(3)Preparation of a drug-loaded DOX functional double-layer gel patch,and evaluation of patch parameters such as its gel fraction,moisturizing ability,and water vapor transmission rate.(4)The DOX in vitro analysis method was established by HPLC to simulate the release of the skin surface in vitro to investigate its release effect,and the functional double-layer hydrogel was used as a medium to test its antibacterial performance.Based on this research,the following conclusions are drawn:(1)Dopamine and polydopamine doping have different degrees of performance improvement on DN hydrogels.Among them,at the optimal concentration,dopamine-doped DN hydrogel has the best mechanical and self-healing properties,and has excellent antifouling performance and continuous skin adhesion.(2)The functional layer nano-Zn O composite hydrogel with suitable performance was successfully screened,and the performance of the developed double-layer gel patch was further improved.The double-layered DOX gel has good stability,and the parameters such as moisturizing performance and water vapor transmission rate meet the requirements of normal skin and minimally invasive physiological environment.(3)Polydopamine has a good encapsulation effect on DOX,the drug loading and encapsulation rate can reach 10.21%and 79.42%,respectively.(4)The functional double-layer hydrogel has good antibacterial effect.The functional double-layer hydrogel patch developed in this research proposes a new way of applying DOX to avoid the severe cardiotoxicity of DOX during injection administration,which is of reference significance for the development of a new DOX administration method.