Preparation And Properties Of Captopril Sustained-Release Drug Doped With Carbon Materials With Different Morphologies

Captopril is one of the first choice drugs for treatment of hypertension,but it is given several times a day,which causes a lot of trouble to most people,increases the time it takes for an active drug to be released in the body.However,one of the key factors for sustained-release agents to achieve a good sustained-release effect is the availability of appropriate carriers.The existing slow-release carriers（polylactic acid,chitosan,etc）have less drug load,so it is necessary to look for carriers that can carry more drug load.Carbon materials as drug carriers have many advantages,and its non-toxic harmless,but also can change the loading of drugs.Therefore,as a drug carrier,it has a wide application prospect in the study of drug sustained release.This thesis consists of three parts as follows:1)Hollow carbon tubes（HCN）were prepared by“grinding”method.During the whole experiment,3-aminophenol（3-AP）was used as the sole carbon and nitrogen source,HAP nanowires（hydroxylapatite）were used as the template.When it was used as captopril drug carrier,the adsorption capacity was affected by the concentration of the drug and the adsorption time.When the concentration of the drug reached 100 mg·L^-1,the adsorption capacity reached saturation,and the maximum adsorption capacity was135.740 mg·g^-1,the adsorption time was 180 min.When the release time was 18 h,the cumulative release percentage reached the maximum of 80.210%.2)For the first time,hollow carbon spheres（HCS）were prepared by pyrolytic deposition method combined with hard template using only surfactant as carbon source,and cetyl trimethyl ammonium bromide（CTAB）derived carbon was generated in situ under the catalysis of transition metals.When it was used as captopril drug carrier,the adsorption capacity was affected by the concentration of the drug and the adsorption time.When the concentration of the drug reached 100 mg·L^-1,the adsorption capacity reached saturation,and the maximum adsorption capacity was 149.752 mg·g^-1,the adsorption time was 180 min.When the release time was 18 h,the cumulative release percentage reached the maximum of 87.960%.3)MCM-48 mesoporous molecular sieves were synthesized by the previous method（without any treatment）,and then mixed with sulfuric acid to obtain the mesoporous carbon spheres（MCS）.When it was used as captopril drug carrier,the adsorption capacity was affected by the concentration of the drug and the adsorption time.When the concentration of the drug reached 100 mg·L^-1,the adsorption capacity reached saturation,and the maximum adsorption capacity was 126.983 mg·g^-1,the adsorption time was 180min.When the release time was 18 h,the cumulative release percentage reached 76.410%.The whole thesis uses different methods to prepare three carbon carriers with different morphologies:medium carbon nanotubes,hollow carbon spheres and mesoporous carbon spheres.The solution adsorption method is used to assemble and release the captopril drug.During the assembly process,the behavior of the carrier loaded with the drug belongs to monolayer adsorption,the force is uniform,the quasi-second-order kinetic model is used to describe this behavior more accurately.The release process is in accordance with Higuchi plane diffusion model equation and Retger-peppas equation.Among them,the carrier with the best performance for assembling and releasing captopril is hollow carbon sphere.