Kinetics Controlled Self-assembly Of Short Peptide Hydrogel And Biomimetic Mineralization

The self-assembly of peptides is of great significance in many fields,including iomimetic mineralization,biomedicine,chiral optics.As the template for bionic mineralization,peptides can synthesize highly ordered inorganic nanomaterials under mild,non-high temperature and non-high pressure conditions.In this paper,aromatic short peptides were used as the research object to study the peptide-based hydrogel formed by self-assembly under kinetic control and explore the effect of heat treatment on the structure and performance of the peptide hydrogel.Moreover,the self-assembled liquid crystal material based on Fmoc-tripeptide was constructed and used as a template for mineralization to synthesize inorganic metal nanomaterials with controllable structures.Firstly,based on the ferrocene-protected aromatic dipeptide（Fc-FF）,the influence of kinetic factors on the chiral self-assembly of Fc-FF was analyzed by changing the temperature of self-assembly and the water content of the solvent.The assemblies will undergo a sol-gel transition and the chirality of the supramolecular will reverse as the temperature changes.Thermal annealing or quenching of the peptide solution can control the self-assembly of the peptide into materials with different phase behaviors and macroscopic properties.After thermal annealing of the heated peptide solution,large nanoribbons or crystallites will form in the solution.However,the peptide solution quickly formed the self-supporting hydrogel after quenching,and the microscopic morphology and properties of the peptide assemblies were significantly different from nanobelts or microcrystals.In addition,the heating treatment rule also applies to Fmoc-protected aromatic tripeptide hydrogel（Fmoc-FFD）.Furthermore,Fmoc-protected aromatic tripeptide（Fmoc-FFD）was used as the emplate to control the synthesis of ordered titanium dioxide nanofibers,which are used as the catalyst to degrade organic dyes.By adjusting the p H of the solution,Fmoc-FFD self-assembles to form nanostructures with different morphologies.Fmoc-FFD surface shows many carboxylic acid groups,which provides a binding site for the formation of titanium dioxide nanofibers.It is worth noting that when the p H is 6 and 7,Fmoc-FFD self-assembles to form the nematic liquid crystal,and the photocatalytic efficiency of Ti O₂ nanofibers is the highest.The results show that using aromatic short peptides as templates,titanium dioxide nanofibers with controllable photocatalytic activity can be synthesized under mild conditions.In summary,based on aromatic short peptides,the self-assembly pathway and assembly mechanism of short peptides were studied,and their application as a bionic mineralization template was realized.