Research On Cross-coupling And Decarboxylation Reaction Based On Visible Light Catalysis

In recent years,the organic reaction induced by visible light catalysis has attracted widespread attention because of its mild,clean and environmentally friendly green characteristics.Visible light-induced C-H bond functionalization is a method of directly introducing functional groups by activating the C-H bond.It has been widely used in the study of N-arylglycinate Csp³-H functionalization.N-arylglycinate compounds are a kind of Common amino acid esters are themselves important biologically active organic molecules and natural products.Therefore,the functionalization of N-arylglycinate Csp³-H has important research significance.However,reports on such reactions usually use transition metal catalysts and oxidants,and the reaction conditions are harsh.The thesis mainly studies the visible light-induced metal-free catalyzed cross-coupling and decarboxylation reaction to realize the functionalization of N-arylglycinate Csp³-H.The specific research contents are as follows:1.Visible light-induced aerobic oxidation cross-coupling reaction:preparation ofα-indolylglycine derivatives.We report a case of cross dehydrogenation coupling reaction between N-arylglycinate and indole under visible light irradiation,organic dye Rose bengal（RB）as a photocatalyst,and a series ofα-indole with different substituents were prepared.Doleylglycine derivative,and the structure was verified by ¹H NMR,¹³C NMR and MS.At the same time,a possible reaction path is given based on the control experiment.This scheme has good substrate universality and good functional group tolerance.2.Visible light-induced decarboxylation coupling reaction of N-arylglycinate andβ-keto acid.We have carried out a metal-free catalyzed,visible light-induced decarboxylation coupling reaction of N-arylglycinate andβ-keto acid.The reaction does not require other additives,has simple operation,mild reaction conditions and is environmentally friendly.A series ofβ-amino ketones were synthesized under optimal reaction conditions,and the structure was verified by ¹H NMR,¹³C NMR and MS.At the same time,a possible reaction path is given based on the control experiment.