Construction Of Flexible Electrochemical Sensor And Its Application In Ascorbic Acid Detection

Wearable electrochemical sensors can measure disease-related biological analytes conveniently and quickly,and have great potential in personalized medical treatment and clinical diagnosis.In this paper,a simple and low-cost method is used to process the flexible electrode,which is integrated with a potentiostat to build an integrated flexible sensing platform for monitoring ascorbic acid content in sweat.The main content is divided into the following three parts1.Try to use simple lithography,mask deposition and screen printing to process flexible electrode.Carbon is used as working electrode and counter electrode,and silver / silver chloride is used as reference electrode.Gold is used as working electrode and counter electrode,and silver / Ag Cl is also used as reference electrode.The advantages and disadvantages of the three methods were compared,and the simple lithography method was finally determined.The prepared electrode showed high resolution and excellent electrical / mechanical bending performance.2.The prepared flexible electrode was chemically modified.Firstly,platinum nanoparticles were used to modify the electrode to improve the catalytic ability for hydrogen peroxide,and then ascorbic acid oxidase was immobilized in the mixed solution of chitosan / carbon nanotubes.The detection limit of ascorbic acid sensor was 3.8 μ M.The sensitivity was 288.86 μ The detection range was 25-1000 mm-1cm-2 μ M.And the sensor has good selectivity and stability.The mechanical property experiment shows that the detection performance of the sensor is almost not affected in the bending state,3.A potentiostat circuit matched with the flexible electrode is designed,which includes the key signal regulation and processing functions.At the same time,the flexible antenna is designed and fabricated by using electromagnetic field simulation software and micromachining technology.The constant potential circuit and antenna have reliable performance,which greatly improves the compactness and portability of the equipment.