Behavioral And Neurophysiological Abnormalities During Cued Continuous Performance Test In Patients With Mild Traumatic Brain Injury

Objective To investigate features and neural mechanisms of sustained attention and executive function in patients with acute mild traumatic brain injury(mTBI)by comparing and analyzing behavioral and event-related potential of patients and healthy controls.Methods Seventeen patients with acute mTBI and seventeen healthy controls participated in a cued continuous performance test to collected behavioral data and apply 128 channels High density electroencephalogram technique to analyze devent-related potentials.Results1.There were significant differences between the mTBI group and the control group in hitting number [(66.76±3.27),(69.12±1.41)],reaction time[(533.66±144.20)ms,(413.03±94.57)ms],the number of errors of omission [(3.24±3.27),(0.88±1.41)](P<0.05),and no significant differences in the number of false errors [(0.35±1.00),(0.53±0.87)](P>0.05).2.The amplitude of Go-N2 and Nogo-N2 were significantly smaller for the mTBI group than the control group(P<0.05).The main effect of group was significant of N2 amplitude(P<0.05),but main effect of condition and the interaction effect are not significant(P>0.05).Group and condition had no significant main effect and interaction effect on the latency of N2(P>0.05).The amplitude of Go-P3 was significantly smaller for the mTBI group than the control group(P<0.05),while not on the amplitude of Nogo-P3(P > 0.05).The main effect of group and condition were significant of P3 amplitude(P<0.05),but the interaction effect was not significant(P>0.05).Group and condition had no significant main effect and interaction effect on the amplitude of P3(P>0.05).Conclusion Patients with mTBI performance had impairments in sustained attention and executive function,the neuromechanism is the conflict monitoring impairments,may be associated with abnormal activation of anterior cingulate cortex;while spare in response inhibition,may be the prefrontal cortex related network had on obvious impairments.