REGγ Was Involved In The Function And Mechanism Of Skin Wound Healing

Skin wound healing is a complex and orderly physiological process,which can be divided into four stages: hemostasis,inflammation,proliferation and the molding stage.REGγ is an important activator of the 20 S proteasome,which can mediate the degradation of many protein molecules in an ubiquitin-,ATP-independent manner.It has been reported that in the process of treating chronic wound to acute wound with debridement,the level of REGγ was elevated through high-throughput screening,suggesting that REGγ may play a certain biological role in wound healing.In this paper,we found that REGγ deficiency slows down the process of skin wound healing.Which stage of wound healing is mainly affected by REGγ? Preliminary studies found that during the initial inflammatory stage,the macrophage aggregation of REGγ-deficient mice is decreased,and the m RNA level of IL-1β,IL-6 and TNF-α was also decreased,which indicates that REGγ deficiency slows down the inflammatory response in wounds.Next,we detected the influence on the epidermal regeneration stage.Results showed the migration ability of keratinocytes,granulation tissue and angiogenesis was decreased,and the transcription of growth factors such as FGF-7,IGF and VEGF was also deminished in REGγ-deficient mice.In the tissue remodeling phase,the deposition of collagen typeΙin REGγ-deficient mice was decreased.The research of this paper lays a good foundation for further study on the function and molecular mechanism of REGγ in wound healing.