Correlation Of NLR,LMR With Hepatic Encephalopathy In Hepatitis C Cirrhosis

Objective:To evaluate the clinic significance of inflammatory marker,which are neutrophils-lymphocytes ratio(NLR),lymphocytes-mononuclears ratio(LMR),and platelets-lymphocytes ratio(PLR)in predicting hepatitis C cirrhosis with hepatic encephalopathy.Methods:Retrospective analysis of the clinical data was performed on 30 patients with hepatic encephalopathy,and 187 patients with hepatitis c cirrhosis decompensated without hepatic encephalopathy,and they were hospitalized for the first time in the affiliated hospital of yanbian university from January 2011 to December 2019.General information and the first laboratory test results after admission were recorded for both groups,including age,sex,blood routine,liver function,and prothrombin time,etc.In this study,age and albumin were normally distributed,and T-test analysis was used.Gender,nationality,total bilirubin,neutrophils,lymphocytes and platelets were not normally distributed.Kruskal-wallis non-parametric test was used for significance test.Bonferroni correction method was used for comparison between hepatic encephalopathy group and non-hepatic encephalopathy group.NLR,LMR and PLR were calculated based on the results of routine blood tests.ROC curve analysis was used to evaluate the clinical significance of NLR,LMR and PLR in predicting hepatitis C cirrhosis complicated with hepatic encephalopathy.Results:1.Compare hepatic encephalopathy to non-hepatic encephalopathy:in these two groups,patients’age,gender,nationality,TBIL,L,M,PLT have no significant differences.(P>0.05).2.The percentage of Child-pugh B and Child-pugh C in the hepatic encephalopathy group is high,and the proportion of Child-pugh C is significantly higher in the patients with hepatic encephalopathy than that in non-hepatic encephalopathy.(P<0.05).3.ALB of patients with non-hepatic encephalopathy is higher than the patients with hepatic encephalopathy.(P<0.05).PT and N of hepatic encephalopathy group were high than that of non-hepatic encephalopathy group.(P<0.05).4.Univariate analysis showed that NLR(P<0.05)and LMR(P<0.05)were significantly correlated with hepatic encephalopathy,while PLR(P>0.05)was not.Conclusion:NLR and LMR can be used for predictors of Hepatitis C cirrhosis complicated with hepatic encephalopathy,and the best cutoff values are 2.070 and 3.302,respectively.Moreover,they can be applied in the prediction and screening of Hepatitis C cirrhosis complicated with hepatic encephalopathy.