Clinical Effective Analysis Of Esophageal Variceal Ligation Combined With Somatostatin In The Treatment Of Cirrhosis Complicated With Esophageal Variceal Bleeding

Objective:To explore the clinical effect of endoscopic variceal ligation(EVL)c ombined with somatostatin(SS)in the treatment of cirrhosis with esophageal va riceal bleeding(EVB)in Yanbian area.Methods:From January 2014 to December 2018,125 patients with upper gastrointestinal bleeding due to cirrhosis and esophageal varices bleeding admitted in the Affiliated Hospital of Yanbian University were retrospectively analyzed.There were 66 patients in the SS treatment group as the control group,and 59 patients in the SS combined with EVL group as the treatment group.Statistics and analysis of the two groups of patients with general data,early hemostasis rate,early,short-term,long-term rebleeding rate,incidence of adverse reactions and other indicators,and objective to investigate the clinical effect of SS combined with EVL in the treatment of liver cirrhosis complicated with EVB in Yanbian area.Results:(1)In the control group and the treatment group,no rebleeding was observed within 72 hours after the treatment,and there was no significant difference in the early rebleeding rate,the short-term rebleeding rate and mortality between the two groups.But in the long-term rebleeding rate,the data of the treatment group was significantly lower than that of the control group,the difference was statistically.significant(P<0.05).(2)In the treatment group,34 patients(57.63%)had adverse reactions after EVL,including 28 patients(47.46%)with retrosternal pain,4 patients(6.78%)with nausea and 2 patients(3.39%)with dysphagia,and there were 27 patients with esophageal varices(EV)recurrence,the recurrence rate of EV was 45.76%,including 23 cases of severe(GⅢ),4 cases of mild(G Ⅰ),and the average recurrence time of EV was 4.00(2.00-10.00)months.And in the treatment group,compared with the patients with EV in the lower esophagus and the patients with EV in the middle and lower-middle esophagus,the KoreanChinese were significantly more than the Han people,and the difference was statistically significant(P=0.017 and 0.012,respectively),and there was no significant difference between KoreanChinese and Han in other general data,early rebleeding rate,short-term rebleeding rate,long-term rebleeding rate,mortality,the incidence of adverse reactions after EVL,the recurrence rate of EV,recurrence time of EV,recurrence degree of EV and location of EV(P>0.05).Conclusions:(1)Compared with Han with liver cirrhosis,the location of EV in KoreanChinese with liver cirrhosis in Yanbian area is more common in the lower segment of esophagus.(2)The therapeutic effect of EVL combined with SS in the treatment of cirrhosis with EVB in Yanbian area is basically the same as that of single SS in the early hemostasis,the short-term rebleeding and mortality,but the effect in the prevention of long-term rebleeding is significantly better than that of single SS.