Correlation Of RDW,NLR,PLR And The Severity Of Community Acquired Pneumonia Patients

Purposes: This thesis is an attempt to discuss the correlation of Red Blood Cell Distribution Width(RDW),Neutrophil to Lymphocyte Ratio(NLR),Platelet to Lymphocyte Ratio(PLR)and Community Acquired Pneumonia(CAP)patients’ conditions and prognoses,so as to provide the basis for clinical evaluation of the CAP patients’ conditions.Methods: Retrospective analysis of clinical data of 101 CAP patients in our hospital from July 1,2017 to July 1,2019 who meet in the Guidelines for the Diagnosis and Treatment of Adult Community Acquired Pneumonia at the Primary Level(2018).According to the clinical pulmonary infection score(CPIS),it was divided into severe pneumonia group(CPIS> 6 points)and mild pneumonia group(CPIS≤6 points),to compare the differences in white blood cell(WBC),RDW,NLR,PCT,PLR and CRP counts between the two groups;According to the RDW value,it was divided into RDW≥14% group and RDW <14% group,and the differences in PCT,WBC,NLR,PLR and CRP counts were compared between the two groups;According to NLR value it was divided into NLR≥10 group and NLR<10 group,and the differences of PCT,WBC,RDW,PLR,CRP counts were compared between the two groups;According to the median PLR value,it was divided into PLR≥189 group and PLR <189 group.The differences in PCT,WBC,RDW,NLR and CRP counts were compared between the two groups.Pearson rank correlation analysis was used to analyze the correlation between RDW,NLR,PLR and CPIS scores,PCT and CRP.The value of RDW,NLR,PLR,PCT,CRP and RDW,NLR and PLR combined to predict the prognosis value of CAP patients was analyzed by drawing ROC curve.Kaplan-Meier analysis was used to compare the differences in RDW,NLR and PLR survival time between patients with CAP.Result: The levels of PCT,WBC,NLR,RDW,PLR and CRP in the severe group(CPIS>6 points)were higher than those in the mild group(CPIS≤6points)(P<0.05).The levels of PCT,CRP,NLR and PLR in patients with RDW ≥14%were higher than those in RDW <14%(P<0.05).There was no difference in WBC levels between the two groups of patients with RDW ≥ 14% and RDW <14%(P> 0.05).The levels of PCT,WBC,RDW,PLR and CRP in patients with NLR≥ 10 groups were higher than those in NLR<10 groups(P<0.05).The levels of PCT,CRP,RDW and NLR in patients with PLR≥189 group were higher than those in PLR<189 group(P<0.05).There was no difference in WBC levels between the two groups of patients with PLR≥189 group and PLR<189 group(P>0.05).Pearson correlation analysis showed that RDW and CPIS,PCT,CRP were positively correlated(r=0.500,P<0.001;r=0.550,P<0.001;r=0.494,P<0.001);NLR and CPIS,PCT,CRP were positively correlated(r=0.716,P<0.001;r =0.921,P<0.001;r=0.808,P<0.001);PLR and CPIS,PCT,CRP were positively correlated(r=0.594,P<0.001;r=0.830,P<0.001;r=0.659,P<0.001).ROC curve analysis showed that the area under the ROC curve(AUC)of RDW was 0.811,the AUC of NLR was 0.953,the AUC of PLR was 0.808,the AUC of PCT was 0.877,the AUC of CRP was 0.960,and the combination AUC of RDW,NLR and PLR was 0.982.Kaplan-Meier analysis showed that different RDW,NLR and PLR levels had significant differences in the survival time of CAP patients(P<0.05).Conclusion: RDW,NLR and PLR were positively correlated with CPIS score.When we diagnose the CAP,the higher level of RDW,NLR and PLR,the more serious of illness will be,and it will lead to poor prognosis.The combination of RDW,NLR and PLR is relatively valuable for judging the severity of CAP.RDW,NLR and PLR may be used as one of the indicators to predict the prognosis of patients with CAP.