Analysis Of Clinical Features Of Hyperglycemic Hyperosmolar State With Rhabdomyolysis

ObjectiveRaise awareness of Hyperglycemic Hyperosmolar State(HHS) combined with Rhabdomyolysis(RM),and of analyze clinical features of Hyperglycemic Hyperosmolar State combined with Rhabdomyolysis.MethodsThe clinical data came from 108 cases of HHS patients admitted to a tertiary hospital from 2012 to 2019,including 27 cases of HHS combined with RM,which were retrospectively analyzed.According to the diagnostic criteria established by ADA in 2009,it was judged as HHS.For rhabdomyolysis syndrome,serum creatine kinase ≥ 5 times the upper limit of normal reference value(1000 U / L)is the diagnostic criterion.ResultsThe incidence of RM under HHS: 27 of 108 HHS patients had RM,with an incidence rate of 25%;the mortality rate in the HHS group without RM was 16.05%,the mortality rate in the HHS group with RM was 33.33%,and the HHS with RM The mortality rate in the group was significantly higher than that in the HHS group without RM,but the two groups had no statistical significance in terms of mortality;complications in the HHS group with RM(acute kidney injury,myocardial damage,coma,multiple organ dysfunction syndrome))The incidence rate was significantly higher than that of the HHS group without RM(P <0.05);the serum sodium,blood chloride,plasma osmolality,and effective plasma osmolality of the HHS group with RM were significantly higher than those of the HHS group without RM(P<0.05);Blood urea nitrogen,blood creatinine,lactate dehydrogenase,serum uric acid,blood magnesium,alanine aminotransferase,aspartate aminotransferase levels were higher in the HHS group with RM than the HHS group without RM(P <0.05);The blood creatine kinase in the HHS group was significantly higher than that in the HHS group without RM;the HHS group with RM had a gender composition,age,previous history of diabetes,diabetes type,glycosylated hemoglobin,cholesterol,triglyceride,and hospital stay,etc.There is no difference between the HHS group without RM Learn meaning.Conclusions(1)The complications of HHS combined with RM were significantly higher than those of HHS without combined RM(P <0.05).(2)Patients with HHS and RM had significantly higher creatinine,urea nitrogen,alanine aminotransferase,and aspartate aminotransferase than patients without HHS and RM(P<0.05).(3)The higher the levels of blood sodium,blood chloride,plasma osmotic pressure,and effective plasma osmotic pressure,the more likely HHS is to present RM(P <0.05).(4)RM is an acute complication often overlooked by HHS,which can easily lead to severe electrolyte metabolism disorder,acute kidney injury,multiple organ dysfunction syndrome and other high mortality.Early clinical diagnosis and prevention are very important.