Progress In The Application Of Pregabalin In The Perioperative Period Of Artificial Joint Replacement

Background:The whole knee(TKA)and the full hip(THA)joint replacement are common means of treating knee joints and hip diseases at this stage.It can play a certain inhibitory effect on patient joint pain,and it can restore its joint function,thereby increasing the quality of life of patients.However,the pain problem after artificial joint replacement is a key issue that has been facing for a long time.Patients may happen to lag the time and recovery function of the hospital.Therefore,after the joint replacement is replaced,the management of pain during the treatment can help improve the patient’s satisfaction and play a positive role in the early functional exercise.At this stage,more common drugs(such as non-steroidal anti-inflammatory drugs(NSAIDS)and epoxy-2(COX-2)inhibitors)can reduce the demand for patients with postoperative opioids.At the same time,this drug can also have a significant improvement effect on the patient’s postoperative pain.Related studies have pointed out that in addition to the above two drugs can play an important role in postoperative analgesia,Gaba,Pin and Puibabarin can function accordingly.However,The use of pregabalin and the effects of its side effects on patients remain controversial.Objective:Perioperative period for the first time application of small dose of pregabalin,and gradually increase the dose,compared with the perioperative period of the Puibaulin medication program,whether the analgesic effect can be placed,whether the patient can reduce some adverse reactions,can reduce opioid drug consumption and patient discharge time.Methods:A forward-looking,randomized controlled trial was conducted in February 2021,2021.First,the patient was randomly packet.Group A refers to Oral 37.5mg / 2 times,75 mg of Puibabarin,75 mg,75mg.Oral 75 mg Puibarin was taken at 18 o’clock every day after surgery.Group B: 75 mg pregabalin was taken orally only 2 hours before surgery,and 75 mg pregabalin was taken orally at 18 PM every day after surgery.Then,the data is collected and compared to the following three indicators in group A and Group B:(1)VAS pain score;(2)incidence of adverse reactions;(3)discharge time and morphine consumption.Results:There are 60 cases to meet the screening requirements and are voluntary to participate in this study.60 cases were randomly divided into 2 groups,namely a group and Group B,each 30 cases.Comparative A group and B group in age,gender,height,weight,body mass index,ASA rating,preoperative SAS anxiety and self-evaluation scale,SDS depression self-evaluation scale,perioperative analgesic drug use and neurological resistance.There is no statistical difference between the two or the anesthesia type.In the pair comparison,the incidence of adverse reactions(except outside the seal)is concerne,group A was obviously less than the Group B(P<0.05).In terms of morphine consumption,group A is obviously less than the Group B(P <0.05).In terms of VAS pain score,there was no obvious difference in group A and B(P> 0.05).In terms of calm incidence,there was no obvious difference in group A and B group(P> 0.05).As far as the time is discharged time is concerned,there was no obvious difference between group A and B(P> 0.05).Conclusion:The first application of smaller doses in the perioperative period,and gradually increase its application dose,the drug consumption of the patient’s perioperative opioid drug and some adverse reactions have an inhibitory effect,which is better than the traditional Single dose repetition programs are more conducive to patient rehabilitation.