| ObjectivesThe correlation between different human anthropometric indexes(BMI,WC,WHTR,RFM,PI,CI,LAP,ABSI)and non-alcoholic fatty liver disease(NAFLD)in elderly was compared,and the dfferences in efficacy of NAFLD were distinguished.To provide supporting data for health authorities to develop effective prevention and strategies for obesity and non-alcoholic fatty liver disease among elderly residents in the community.MethodsIn this research,random sampling of 2034 community residents over the age of 65 years in the southern community who underwent physical examination in 2019 was recruitedaged.Their height,weight,waist circumference,fasting blood glucose and triglyceride levels were measured.The subjects’ venous blood samples of were collected by professional medical personnel for the evaluation of FBG,triglyceride(TG),and other levels.Abdominal ultrasound was used to detect liver lesions,Anthropometry indexes were calculated,Statistical analyses were performed using SPSS 20.0 for Windows(IBM Corp.).Subjects’ total data for were classified by the presence or absence of NAFLD and stratified by sex.Continuous data are expressed as mean±standard deviation(SD)and compared using the t-test.Categorical data were analyzed using the chi-square test.Comparisons between different anthropometric indices were assessed using Pearson’s test.Logistic regression analysis was used to analyze the relationship between different anthropometric indicators and NAFLD,and correlation was measured by using odds ratios(OR)and 95%confidence intervals(CI).The area under the curve(AUC)in the receiver operating characteristic(ROC)analysis was calculated to assess the diagnostic ability of all the anthropometric indices for screening for NAFLD and determine the optimal cutoff point with the Youden’s index(sensitivity+specificity-1 was the highest).All statistical comparisons were two-tailed,and P-values<0.05 were considered significant.Results1.This study included 994 men and 1495women,Among these subjects,271(27.3%)men and 539(36.1%)women were diagnosed with NAFLD by US,respectively.In both men and women,participants in the NAFLD group exhibited significantly higher values of hypertension,FBG,BMI,WC,WHtR,RFM,PI,CI,and LAP than those in the control group,while ABSI was only statistically significant in male population(male:p<0.05,female:p=0.8).2.With the increase of the quartile level of each anthropometric index,the OR value corresponding to each anthropometric index also gradually increased(P<0.001),except for ABSI and CI in women.After adjusting for confounding factors,a 1-SD increment change for most adiposity indexes was associated with a higher risk of NAFLD in the sex-specific and age-specific groups.In men,WC had the highest OR in the≤70-year-old group(6.22),followed by RFM(4.47)in the 70-80-year-old group,and BMI had the highest OR in women aged 80 years or older(3.67).In women,RFM had the highest OR in the ≤70-year-old group(3.52),followed by LAP(2.90)in the 70-80-year-old group,and WC had the highest OR in women aged 80 years or older(3.18).3.In the ROC curve,LAP had the highest AUC and highest cutoff value.When the cutoff values were 0.831 in men and 0.770 in women,Youden’s indexes(men:sum of sensitivity,80.8%;specificity,71.5%;women:74.6%and 65.0%,respectively)were the largest.4.The optimal cut-off value for anthropometric screening of NAFLD in older menwas:BMI:24.01kg/m~2,WC:90.00cm,WHtR:0.53,RFM:26.04,PI:15.09kg/m~3,CI:1.26,LAP:36.15cm.mmol/l,ABSI:0.079,respectively.The optimal cut-off value for anthropometric screening of NAFLD in older women was BMI:23.99 kg/m~2,WC:87.75cm,WHtR:0.57,RFM:40.89,PI:16.20 kg/m~3,CI:1.28,LAP:49.17cm.mmol/l,ABSI:0.081,respectively.Conclusions1.BMI,WC,WHtR,RFM,PI,CI and LAP were positively correlated with the risk of NAFLD in both men and women,The NAFLD and control groups were significantly different in terms of ABSI in men but not in women.2.LAP is simple and easy to measure,and it is very suitable for research and as a practical tool for screening and studying NAFLD in the high-risk community elderly population.Its diagnostic accuracy of LAP is higher in men than in women.Therefore,elderly men with high levels of LAP need to be vigilant,and diet and exercise intervention should be carried out as soon as possible for weight loss.3.The optimal cut-off value for anthropometric screening of NAFLD in older men was:BMI:24.05kg/m~2,WC:90.5cm,WHtR:0.53,RFM:26.13,PI:15.03kg/m~3,CIs1.27,LAP:36.44cm.mmol/l,ABSI:0.079,respectively.The optimal cut-off value for anthropometric screening of NAFLD in older women was BMI:23.94 kg/m~2,WC:86.5cm,WHtR:0.55,RFM:40.24,PI:16.02 kg/m~3,CI:1.28,LAP:46.20cm.mmol/l,ABSI:0.080,These results suggest that obesity intervention can be carried out in advance by using anthropometric indicators to assess the degree of obesity,thus helping to achieve early screening and later treatment of non-alcoholic fatty liver disease. |
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