Detection Of Descending Spinal Nerve Signal Pathway Based On Electronic Informatics

Spinal cord injury is a serious traumatic disease of central nervous system,which affects the patients’ living ability and life quality.Since the regeneration of injured neurons and the recovery of axonal conduction function are difficult,the treatment of spinal cord injury has become a worldwide problem.With the cross-fusion of microelectronics and biomedicine,it has become possible to rebuild the motor function after spinal cord injury by using microelectronic neural bridge technology.In the realization process,the implantation location of the detection electrode to collect the brain movement control signal and the spinal cord stimulation electrode to induce the hindlimb motion should be solved.Therefore,the electrical method was used to detect the descending nerve signal pathway in the rat spinal cord,to provide accurate electrode location guidance for the rebuilding of motor function,and to explore a new approach for the rehabilitation treatment of spinal cord injury from the perspective of electronic informatics.In order to find the implant position of the detection electrode,it is most important to determine the conduction pathway of the motor control signal in the spinal cord.The cerebral motor function of rats was mapped by intracortical microstimulation to determine the appropriate sites for controlling hindlimb motion.While inducing the hindlimb motion,effective evoked potentials were recorded in the spinal cord.By analyzing the correlation between evoked potentials,the key sites of the conduction pathway were finally determined,which can provide guidance for the implantation of detection electrode to collect the brain movement control signal.Intraspinal microstimulations were performed on Lumbar spinal cord which can transmit hindlimb motion control signals in rats,and the location coordinates of hip,knee and ankle joint motion were recorded.The distribution of spinal motor function regions were obtained after normalizing coordinate.The core region was defined as the overlapping part of the superimposed function region of the same motion in multiple experimental subjects,and the 3D map of the motor function core region in the rats was drawn to reduce the differences between individuals,the secondary injury to the spinal cord caused by multiple implantation,improve the accuracy of electrode implantation and the applicability of the map.That can provide a reference for the implantation of spinal stimulation electrodes to control hindlimb motion.To study the effects of spinal cord injury on the core region in rats,comparative experiments were performed from three aspects: injury model,injury segment and injury time.Compared with healthy rats,complete spinal cord injury may cause the core region of motor function to migrate to the injured end.The longer the post-transected time,the longer the migration distance.This provides a more accurate and effective guidance for the implantation of stimulation electrode with different situations.