Investigation On Curative Effects Of Botulinum Toxin Type A Combined With Glucocorticoid On Keloid

Objective: To investigate the clinical efficacy of botulinum toxin type A for injection combined with prednisolone acetate in the treatment of keloid and its effect on serum TGF-β1 content of patients.Methods: A total of 86 patients with keloid diagnosis admitted to the Affiliated Hospital of Qinghai University from November 2019 to November 2020 were collected as the research subjects,and the patients were randomly divided into observation group(43 cases)and control group(43 cases).The observation group was given botulinum toxin type A and prednisolone acetate alternately at two-week intervals,and botulinum toxin type A was injected for the first time for a total of 6 treatments;The control group was given a single prednisolone acetate injection for local intralesional injection once every two weeks for a total of 6 times.Before and after treatment,the efficacy of the two groups of patients was compared through the Vancouver Scar Scale(VSS)and the Patient and Observer Scar Assessment Scale(POSAS),Measure the level of TGF-β1before and after treatment and the incidence of adverse reactions,To compare the clinical efficacy of botulinum toxin type A combined with glucocorticoids in the treatment of keloids.Results: Before treatment,the observation group and the control group had no statistical difference in general data and evaluation indicators(P>0.05),and they were comparable;after treatment,the improvement of VSS and POSAS scores in the observation group was higher than that of the control group(P<0.05);The improvement of itching and pain scores in the POSAS score of the observation group was significantly higher than that of the control group(P<0.05);after treatment,the serum TGFβ1 of the two groups decreased compared with before,and the degree of decrease in the observation group was higher than that of the treatment group.Conculutions: 1.Botulinum toxin type A combined with glucocorticoids is better than glucocorticoid therapy alone in the treatment of keloids.The combined treatment has lower side effects and is particularly advantageous in relieving the pain and itching of patients with keloids.2.After treatment with botulinum toxin type A combined with glucocorticoids,serum TGFβ1 decreased more significantly.Botulinum toxin type A may inhibit keloids through TGFβ1 related signaling pathways.