Clinical Application Of Concentrated Growth Factors In The Treatment Of Diabetic Foot Ulcers

Background:As the third generation of platelet concentrates,concentrated growth factor(CGF)was first prepared by Sacco in 2006.This new blood extract has been widely used in wound healing and tissue regeneration in stomatology,orthopedics and other departments because of its advantages of promoting wound healing,reducing postoperative reaction,enhancing bone regeneration,low preparation cost and good biocompatibility.Diabetic foot,due to its lower extremity vascular neuropathy,leads to the lack of blood supply and neurotrophic effect of lower extremity microcirculation disturbance.In addition,many factors such as infection work together,resulting in the difficulty of self-healing of diabetic foot ulcer wound and the formation of chronic refractory wound,which brings inconvenience to the life of patients.The purpose of this study was to prepare CGF gel and gel membrane by variable speed centrifugation from venous blood.After debridement of diabetic foot wounds,CGF gel membrane was applied on the surface of the wounds to explore the effect of concentrated growth factor fibrin on the healing of diabetic foot wounds,and preliminarily evaluate the safety,feasibility and effectiveness of concentrated growth factor fibrin in the treatment of diabetic foot ulcer wounds.Methods:1.Intervention method:According to the inclusion and exclusion criteria,50diabetic foot patients(including patients with Wagner grade 1～3)who need to be hospitalized for debridement treatment from March 2019 to September 2020 in the Plastic Surgery Department of the Second Affiliated Hospital of Anhui Medical University were randomly divided into the experimental group As with the control group,patients in both groups were given basic treatments such as hypoglycemic,blood pressure control,blood lipid adjustment,nerve nutrition,microcirculation improvement,anti-infection,and wound debridement according to their condition,so that the patients’metabolism was stabilized and wound infections were controlled.After debridement of the wound,external application of CGF fibrin gel membrane was applied to the wound to bandage the wound.In the control group,only the wound was debrided and then bandaged.The last two groups of patients were treated with dressing changes every other day and based on the growth and healing of the wound granulation The condition and absorption of CGF gel film should be covered by CGF gel film again or simple debridement,and then the time taken to heal the wound and the wound healing rate[(Original surface area-unhealed wound Area)/original area×100%],wound healing rate(number of people cured/total number of people×100%),etc.It is concluded whether concentrated growth factor fibrin can promote wound healing and shorten the hospitalization time of patients.Results:After systematic treatment and curative effect evaluation,relevant concl usions can be drawn.There were 25 patients in the experimental group and the control group,including 15 males,aged 50-73 years,10 females,aged 58-70 y ears,with an average age of(62.76±7.20)years and an average wound area of(9.30±2.55)cm~2.There were 13 males aged 49–75 years old and 12females aged 55–74 years old in the experimental group,with an average age of(64.12±8.17)years old and an average wound area of(9.80±3.03)cm~2.There was no significant difference in the general data between the two gr oups(P>0.05).There was significant difference in wound healing rate betwe en the experimental group and the control group at the first week,the second w eek and the fourth week(P<0.05).There was no significant difference in w ound healing rate at the eighth week(P>0.05).There was no statistically si gnificant difference in the cure rate between the experimental group and the con trol group at the first and eighth weeks(P<0.05),and there was statistically significant difference in the cure rate at the second and fourth weeks,(P<0.05);The wound healing time of the experimental group was(21.88±11.81)days,and that of the control group was(36.85±9.53)days,the difference w as statistically significant(P<0.05).Conclusion:CGF can be used in the treatment of diabetic foot wounds without obvious adverse reactions,and can accelerate wound healing and significantly r educe hospitalization time...