Analysis Of Distribution And Drug Resistance Of Pathogenic Bacteria In Burned Patients In New And Old Ward

Objective The distribution and drug sensitivity of pathogens in the new and old burn ward in recent 2 years were compared and analyzed.Methods Collect the patients with total body surface area(TBSA)≥30% in the old and new ward of the Department of Burn,First Affiliated Hospital of Anhui Medical University from October 2017 to October 2019 were collected respectively.Strains isolated from wound secretions,blood,urine,arteriovenous catheters,tracheal tubes or sputum specimens,count the types of bacteria and the drug resistance rate of dominant strains.Chi-square test was used to compare the differences in the detection rate and drug resistance rate of major pathogens in old and new burn ward.Results Gram-negative bacteria was the main pathogen detected in the old and new ward(76.02%,79.80%,respectively).The difference in the total detection rate was not statistically significant(P>0.05).Klebsiella pneumoniae was the most frequently detected gram-negative bacteria in the new ward,and the difference in detection rate was not statistically significant(P>0.05).The drug resistance rates of piperacillin/tazobactam,cefepime,and carbapenems were significantly lower than those of the old ward(P<0.05).Pseudomonas aeruginosa was the first dominant strain detected in the old ward and its detection rate was significantly higher than that in the new ward.The drug resistance rates of ciprofloxacin,cefoperazone/sulbactam and piperacillin/tazobactam were significantly higher than those of the new ward(P < 0.05).In addition,the detection rates of enterobacter cloacae and escherichia coli in the new area were higher than those in the old ward,but the difference in detection rates of the second dominant strain acinetobacter baumannii in the old ward was not statistically significant.Staphylococcus aureus was the most commonly detected gram-positive bacteria(4.08% and 5.30% respectively),all of which were methicillin-resistant Staphylo Co CCus aureus(MRSA),There was no statistically significant difference in the detection rate between the new and old wards.Although Staphylococcus aureus resistant to linezolid and vancomycin has not been detected,the overall drug resistance is serious and the situation is not optimistic.The difference in resistance rate is not statistically significant(P> 0.05).Infections caused by fungal strains cannot be ignored.Conclusions There are significant differences in the distribution of pathogenic bacteria and drug resistance among hospitalized patients in the new and old wards.Strengthening the management of the environment in burn ward and standardizing the clinical use of antibiotics can be an effective measure to control the emergence of drug-resistant strains.