The Effect Of TEAS And Dexmedetomidine On Postoperative Cognitive Dysfunction In Elderly

Objective:Through the detection of S100β protein and MMSE score,to explore the application of transcutaneous electrical acupoint stimulation(TEAS),dexmedetomidine(DEX),and the combined application of the two to treat postoperative cognitive dysfunction in elderly patients undergoing laparoscopic radical bladder cancer surgery(POCD).explore the effect of transcutaneous acupoint electrical stimulation(TEAS)combined with dexmedetomidine(DEX)on postoperative cognitive dysfunction(POCD)in elderly patients undergoing laparoscopic radical bladder cancer surgery.Methods:Select Shanxi Provincial People’s Hospital 120 elderly patients who underwent elective laparoscopic radical bladder cancer surgery from May 2019 to February 2021.The patients were randomly divided into: control group(group A,n=20),TEAS group(group B,n =30),DEX group(C group,n=30),TEAS+DEX group(D group,n=30).Group A underwent conventional anesthesia;group B was stimulated bilateral Baihui,Neiguan,Zusanli,Sanyinjiao at 10 min before induction of anesthesia until the end of the operation;group C was pumped with dexmedetomidine 10 min before the induction of anesthesia until the end of the operation In group D,dexmedetomidine was pumped with acupoint stimulation 10 minutes before induction of anesthesia until the end of the operation.3.Main outcome measure : 1)evaluating MMSE score(preoperative 1d,postoperative 3d,postoperative 5d,postoperative 7d)for cognitive function testing;2)calculating the incidence of POCD;3)detecting the level of S100β protein(preoperative,Surgery completed).Results:1.Compared with before anesthesia,the MMSE scores of the four groups decreased at 1 day after operation,the difference was statistically significant(P<0.05);the MMSE scores of group A decreased at 3 days after operation,the difference was statistically significant(P<0.05),B,C There was no statistically significant difference in MMSE scores in group D(P>0.05);there was no significant difference in MMSE scores in the four groups at 5d and 7d after operation(P>0.05).Compared with group A,the MMSE scores of groups B,C,and D increased at 1d and 3d after operation,the difference was statistically significant(P<0.05),and the differences between the three groups were not statistically significant(P>0.05).2.Compared with group A,the incidence of POCD in groups B,C,and D decreased,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of POCD among the three groups B,C,and D(P>0.05).2.Compared with group A,the incidence of POCD in groups B,C,and D was lower,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of POCD among groups B,C,and D(P>0.05).).3.Compared with group A,the level of S100β protein before and after the operation in groups B,C,and D decreased,and the difference was statistically significant(P<0.05);compared with groups B and C,the level of S100β protein in group D decreased,The difference was statistically significant(P<0.05),and the difference between groups B and C was not statistically significant(P>0.05).Conclusion:1.Both TEAS and DEX can reduce the incidence of postoperative cognitive dysfunction,but the combination of the two does not significantly reduce the incidence.2.TEAS combined with DEX can reduce the content of S100β protein more than simply using TEAS and DEX,which can better protect the brain.