Effect Of Endotracheal Administration Of Dexmedetomidine And Lidocaine On Extubation Response In Hypertensive Patients During Recovery From General Anesthesia

Objective:To compare the effects of endotracheal administration of dexmedetomidine and lidocaine on extubation reaction during awakening period of general anesthesia.Methods:Eighty patients with hypertension who were treated with elective surgery under general anesthesia in our hospital were randomly divided into two groups:dexmedetomidine group（group D）,40 cases,lidocaine group（group L）,40 cases.Dexmedetomidine 0.5 ug/kg（D Group）and lidocaine 1.5 mg/kg（L Group）were given by endotracheal administration half an hour before the end of surgery.Values for heart rate（HR）,mean arterial pressure（MAP）were recorded just before（D₀）and 5,10,15（D₁,D₂,D₃）min after the study drug administration,at extubation（T₀）and 1,2,5,10min after extubation（T₁,T₂,T₃,T₄）.Respiratory rate,oxygen saturation and airway responses like coughing,breath-holding,sness,laryngospasm/bronchospasm,nausea and vomiting were recorded only at extubation（T₀）and 1,2,5,10 min after extubation（T₁,T₂,T₃,T₄）.After extubation all these patients were also observed for sedation by Ramsey sedation score and record the extubation time.Results:At the time of T₀,T₁and T₂,HR and MAP of the two groups were increased compared with the base values,and the increase rate of group D was significantly lower than that of group L,the difference was statistically significant（P<0.05）.The extubation time in group D was not prolonged compared with group L,but the sedation score in group D was significantly higher than that in group L,and the incidence of airway adverse reactions in group D was lower than that in group L,with statistical significance（P<0.05）.Conclusion:Before extubation,intra-airway administration of dexmedetomidine and lidocaine can alleviate extubation reactions and reduce adverse reactions caused by extubation to a certain extent,and airway administration of dexmedetomidine is more effective.