| ObjectiveTo explore the correlation between Potentially Inappropriate Medication(PIM)and frailty in elderly diabetic patients in the community,and to analyze the impact of Potentially inappropriate medication on frailty and the associations with various frailty phenotypes,so as to raise people’s attention to medication issues.Reduce the utilization rate of PIM and delay the occurrence and development of frailty.MethodsA total of 319 elderly diabetic patients over 60 years old who met the standards of admission and discharge for physical examination and participated in health education in a community health service center in Xi ’an from July 2020 to January 2021 were selected to collect relevant information such as gender,age,height,weight,BMI,marital status,smoking,monthly income and education background.FRAIL phenotype and Criteria for Judging Potential Improper medication of Older People in China were respectively used to evaluate the FRAIL status and potential inappropriatemedication of selected elderly diabetics.Statistical methods such as analysis of variance,chi-square test,Spearman correlation test and multiple regression analysis were used to analyze the fission status of elderly diabetic patients,potential inappropriate drug use and the correlation between some factors and fission of elderly diabetic patients.P<0.05 was considered statistically significant Results1.A total of 319 elderly diabetic patients who met the standards of sodium and exhaust were selected,including 129 males(40.4%),190 females(59.6%),117 non-frailty elderly(36.7%),144 patients(45.1%)in the pre-frailty stage,and 58 patients(18.2%)in the frailty stage.2.There were differences in frailty degree between the elderly diabetic patients and age,height,weight,BMI,marital status,smoking,monthly income and educational background(P<0.05).Spearman correlation analysis showed that frailty was positively correlated with age,weight and BMI,and the correlation coefficients were 0.317,0.383,0.206(P<0.05).Chi-square test was used to analyze the correlation between frailty and comorbidities and multidrug.3.The study found that the incidence of at least one PIM,at least two PIM and at least three PIM in elderly diabetic patients was 58.0%,23.8%,and 14.1%,respectively;The difference between the number of PIM and the frailty degree was statistically significant.PIM was more common in endocrine system(48.1%),cardiovascular system(23.1%)and digestive system(15.9%).Common PIM drugs include insulin,clopidogrel,non-steroidal anti-inflammatory drugs and benzodiazepines in related disease states.4.The comparison of frailty phenotype with PIM group showed that there were differences among the three groups(P<0.05),such as not being able to go up a flight of stairs,suffering from more than 5 diseases at the same time and feeling of fatigue;There were no significant differences in body weight loss and not walking 500m(P<0.05).5.There was a correlation between the number of drugs and the occurrence of PIM(P<0.05).6.The results of multiple ordered Logistic regression analysis and adjustment of control variables showed that there was statistical significance between PIM and frailty.The occurrence of PIM could increase the risk of frailty(P<0.05)(OR value was 28.679,95%CI: 0.764-1.646),and PIM was a risk factor for frailty.Conclusion(1)Age,weight and BMI are risk factors for frailty(2)The phenomenon of potential inappropriate medication in elderly diabetic pati ents in the community is serious,and the common potential inappropriate medicatio n includes insulin,clopidogrel,non-steroidal anti-inflammatory drugs in related dise ase states.and benzodiazepines(3)PIM can increase the occurrence risk of frailty in elderly diabetic patients,a nd PIM is a risk factor for frailty. |
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