The Association Between IL-6,TNF-α,CRP In Serum With Disease Activity And Prognosis Of Inflammatory Bowel Disease

Aim: We aimed to explore association between IL-6、IL-10、IL-17、TNF-α and CRP in serum and disease activity and prognosis of IBD.Methods: We included patients who were diagnosed as IBD at The first hospital of China Medical University in 2018-2020 and collected patients’ information.Totally,100 patients were investigated and 60 UC patients and 40 CD patients were included.For every UC and CD patients,we evaluated their clinical and endoscopic disease activity and extent by CDAI,Mayo,UCEIS and SES-CD score systems.At baseline(the 0 week),we collected the value of IL-6,10,17,TNF-α and CRP in serum of included patients and the results of colonoscopy.After systematic therapy for 14 weeks,we calculated the difference value of CRP(△CRP)and evaluated the improvement of intestinal mucosal lesions again according to the results of colonoscopy.We analyzed the collected data with the statistical methods of the Spearman,Mann-Whitney-U test,Kruskal-Wallis test and Logistic Regression analysis by SPSS statistical software.Results: 1.In UC patients,at the baseline,CRP,IL-6,IL-10 and TNF-α are related to disease severity positively.CRP,IL-6 and TNF-α are related to endoscopic disease activity positively.In CD patients,IL-6 is related to disease activity positively.2.IL-6is the most important factor that affect the disease severity,and the higher the value of IL-6,the more severe the disease.3.In UC patients,CRP,IL-6,IL-10,△CRP are related with clinical response.CRP,IL-6 and △CRP are related with endoscopic response.In CD patients,CRP and TNF-α are related with clinical response positively.4.There is no significant difference between CRP,IL-6,IL-10,IL-17,TNF-α in UC and CD patients by comparative analysis.Conclusion:1.In UC patients,CRP,IL-6,IL-10 and TNF-α may be predictive indicators for disease severity and mucosal inflammatory activity.In CD patients,IL-6 may be indicators for disease severity and mucosal inflammatory activity.IL-6 is the most important determined factor for disease severity in UC and CD.2.In UC patients,△CRP and IL-6 will be likely to be predictive indicators for clinical and intestinal mucosal healing.It’s more possible to get to clinical response with the higher value of CRP,IL-6,IL-10,△CRP and it’s more possible to get to endoscopic response with the higher value of CRP、IL-6、△CRP.In CD patients,TNF-α could be predictive for intestinal mucosal healing.It’s more possible to get to clinical response with the higher value of CRP and TNF-α.3.In the study,△CRP,CRP,IL-6,IL-10,IL-17 and TNF-α did not contribute to differential diagnosis between UC and CD.