Expression And Effect Of MRP8/14 In Body Liquid From Individuals With Periodontitis And Rheumatoid Arthritis

Objectives:To analysis the level of myeloid-related protein(MRP)8/14 of body liquid from individuals with periodontitis(PD)/periodontitis and rheumatoid arthritis(PR),or healthy controls,then evaluate potential of MRP8/14 in the interaction of periodontitis and rheumatoid arthritis.Methods:This study was included 75 patients were selected(25)healthy subjects,patients with periodontitis(25),and patients with rheumatoid arthritis with periodontitis(25),record the age,sex,periodontal Pocket explore Clinical deep degree(Pocket probing the depth,PPD),Plaque index(Plaque index,PI),attachment loss(Clinical attachment level,CAL)and Bleeding index(Bleeding on probing,BOP).Saliva,gingival crevicular fluid and peripheral blood were collected,and the concentrations of MRP8 and MRP14 were detected by ELISA.SPSS20.0 software package was used to conduct statistical analysis on the experimental data.Results: There was no significant difference in age and sex among all groups(P>0.05).In the periodontitis group and the periodontitis with rheumatoid joint group,the proportion of female subjects was significantly higher than that of male subjects(P< 0.05).The elevels of PD,PI,CAL and BOP in the healthy group were significantly lower than those in the periodontitis group,and in the periodontitis with rheumatoid joint group(P< 0.05),the levels of CAL and BOP in the PR group were higher than those in the PD group(P< 0.05).The levels of MRP8 and MRP14 in saliva,gingival creval fluid and peripheral blood in healthy subjects were significantly lower than those in periodontitis group and rheumatoid joint group(P< 0.05).The levels of MRP8 and MRP14 in gingival crevicular fluid and peripheral blood serum of subjects with different degrees of periodontitis were compared.The levels of MRP8 and MRP14 in gingival crevicular fluid and peripheral blood serum of subjects with moderate and severe periodontitis in PR group were significantly higher than those in PD group(P< 0.05),and there was no significant statistical difference in other comparisons.Conclusion: Rheumatoid arthritis can promote periodontitis to some extent,and MRP8 and MRP14 can play a role in their interaction.