Hepatitis C Virus In The Epidemic Of Childbearing Age Crowd And Mother-to-child Transmission (PMTCT) Survey: 5 Years Clinical Research Based On The Hospital Data

Objective: The prevalence of hepatitis C virus(HCV)infection is usually evaluated according to the current positive rate of anti-HCV antibodies,and the positive rate of HCVRNA is considered to be the main standard of clinical antiviral therapy.In this study,anti-HCV and HCVRNA detection methods were used to investigate the situation of HCV infection in Liaoning province in recent 5 years,and to explore the situation of serum HCV infection in childbearing age population and hepatitis C virus infection in newborns born by serum anti-HCV positive mothers,so as to provide basis for clinical screening of high risk population for hepatitis C and reasonable intervention to reduce mother-to-infant transmission of hepatitis C.Methods: In this study,patients who were tested for serum anti-HCV in XX Hospital from January 1,2015 to December 31,2019,including parturient women and women receiving assisted reproductive treatment in assisted reproductive center as childbearing age population,and male patients receiving assisted reproductive therapy as control group,anti-HCV production was detected by chemiluminescence and serum HCV RNA was detected by Roche COBAS Taq Man(CTM)analyzer.If the anti-HCV was positive,the serum HCV RNA detection results were extracted.If multiple sets of laboratory results are available,use the first set of anti-HCV and HCV RNA results.To explore the situation of serum HCV infection in childbearing age population and hepatitis C virus infection in newborns born by serum anti-HCV positive mothers.Results: The number of anti-HCV test cases from 2015 to 2019 was 166551,178929,199196,200807,211073,respectively.The number of male patients with positive anti-HCV test from 2015 to 2019 was 1295,1247,respectively,while the number of female patients with anti-HCV positive from 2015 to 2019 was 1309,1378,1378,respectively.At the same time,the number of female patients with anti-HCV positive from 2015 to 2019 was 1379,1378,1378,1211,1266,respectively.The positive rate of anti-HCV in male patients decreased from 1.86% in 2015 to 1.30% in 2019.The positive rate of anti-HCV in female patients decreased from 1.35% in 2015 to 0.98% in 2019,showing a significant downward trend from 2015 to 2019(P < 0.001 for males,P < 0.001 for females,P < 0.001 for females,and 66.388 for females).The positive rate of anti-HCV was also significantly different according to sex.The positive rate of anti-HCV in males was significantly higher than that in females,and the difference was statistically significant(from 2015 to 2019,P < 0.001,laboratory~2= 69.558,66.335,35.394,45.059,47.886).The positive rate of anti-HCV was also statistically significant according to age stratification in the past five years.The positive rate of anti-HCV in childbearing age population was lower than that in general population.At present,mother-to-child transmission has not been found in our statistical data.Conclusion: The anti-HCV infection rate of the general population in Liaoning Province is about 1.04%,which is higher than the national HCV infection survey report.About42% of anti-HCV positive patients also tested positive for HCVRNA.The positive rate of anti-HCV is closely related to sex and age,and there is no significant difference between the positive rate of anti-HCV and gender in childbearing age.There is no mother-to-infant transmission in the pregnant women included in this study,suggesting that it is very necessary to carry out antiviral therapy before childbearing in HCV positive childbearing age.In addition,attention should be paid to improve the level of screening,promote timely intervention and prevent the spread of infection.