Study On The Relationship Between Exposure To Severe Famine In Early Life And The Risk Of Metabolic Syndrome In Adulthood

Objective:To explore the relationship between exposure to severe famine in early life and the risk of metabolic syndrome in adulthood.Methods:From May 2011 to October 2011,10140 permanent residents over 40 years old in Yunyan District of Guiyang City were randomly selected,including 3856 people born before and after 3 years of natural disasters in China.The subjects were divided into five groups according to the age of birth: late children famine exposure group(born on October 1,1952 to September 30,1954,n=959),middle children famine exposure group(born on October 1,1954 to September 30,1956,n=925),early childhood famine exposure group(born on October 1,1956 to September 30,1958,n=922),fetal famine exposure group(born on October 1,1959 to September 30,1961,n=518),the non famine exposure group(born on October 1,1962 on September 30,1964,n=532).Diagnostic criteria of metabolic syndrome:(1)central obesity): waist circumference ≥90cm for men and ≥85cm for women.(2)Hypertension: the blood pressure ≥ 130/85 mmhg and/or has been confirmed as the treatment of hypertension.(3)Hyperglycemia: fasting blood glucose ≥6.1mmol/L and/or diabetes mellitus has been diagnosed and treated.(4)Fasting TG≥1.70mmol/L.(5)Fasting HDL-C < 1.04mmol/L.,Three or more of the above can be diagnosed.The above has three or more diagnostic items.Logistic regression model was used to analyze the impact of severe famine exposure in early life on the risk of metabolic syndrome in adulthood.Results:The prevalence of metabolic syndrome was 27.7%,25.1%,22.7%,11.8% in the late childhood,middle childhood,early childhood,and fetal famine exposure groups respectively,the prevalence of metabolic syndrome in the non famine exposure group was 12.7%,and the prevalence of metabolic syndrome in different famine exposure groups was statistically different(p<0.05).After adjusting for confounding factors,the risk of metabolic syndrome in children with middle-term famine exposure was higher than that in non famine exposure group(OR = 1.598;95% CI = 1.148-2.224,p =0.005),and the risk of metabolic syndrome in children with late famine exposure was higher than that in non famine exposure group(OR = 1.410;95% CI = 1.017-1.953,p= 0.039).After stratifying the gender of men and women and adjusting for confounding factors,the risk of metabolic syndrome in the mid-term famine exposure group of female children increased compared with the non-famine exposure group(OR=1.696;95%CI=1.165-2.468,p=0.006),But there is no correlation between the two in the male group.Conclusions:Experiencing severe famine early in life will increase the risk of metabolic syndrome in adulthood,especially in the middle and later stages of childhood.In addition,in terms of gender differences,among women,the risk of developing metabolic syndrome in adulthood is higher when exposed to severe famine in childhood,but there is no association between the two in men.