Clinical Study Of The Effect Of Tenofovir Application On Creatine Kinase-MB Detection In Aids Patients

Objective:To demonstrate the effect of tenofovir application on CK-MB activity detection in HIV infected patients and explore its mechanism.Methods:1.A retrospective study was conducted among 170 treated outpatients who visited the HIV Clinic of The First Hospital of Changsha from September 2019 to December 2019.According to tenofovir dipivoxil fumarate(TDF)was included in the chemotherapy protocol or not,they were divided into TDF group and non-TDF group.CK-MB activity and CK-MB mass concentration were compared between the two groups.Meanwhile,the correlations between CK-MB activity and CK-MB mass concentration in each group were analyzed.2.Compare creatine kinase(CK)activity,lactate dehydrogenase(LDH)activity and myoglobin(Mb)concentration between TDF group and non-TDF group.3.The differences of aspartate aminotransferase(AST),alanine aminotransferase(ALT),creatinine(Crea),cystatin C(Cys C),inorganic phosphorus(P),lactic acid(LAC),β2-microglobulin(BMG)and alkaline phosphatase(ALP)in peripheral blood between TDF group and non-TDF group were compared to explore the possible mechanism of abnormal expression of creatine kinase isoenzyme.Results:1.The CK-MB activity of TDF group was higher than that of non-TDF group(P <0.001),while there was no significant difference in CK-MB mass concentration between TDF group and non-TDF group(P >0.05).The correlation coefficients of CK-MB activity to CK-MB mass concentration in non-TDF group and TDF group were 0.963 and 0.094 respectively.2.There were no significant differences in CK activity,LDH activity and Mb concentration between TDF group and non-TDF group(P >0.05)statistically.3.There were significant differences in AST,ALT and ALP between TDF group and non TDF group(P <0.05),while there were no significant differences in Cr,Cys C,P,LAC and BMG between these two groups(P >0.05).Conclusions:1.Treatment of HIV infection with TDF leads to pseudoelevation of serum CK-MB activity detected by immunosuppression method.2.Pseudoelevation of Creatine kinase-MB activity after TDF treatment may be relate to slight changes of liver metabolism and/or bone injury.