| Bacterial infection is one of the reasons that cause long term long-term unhealing of wounds.Single method to treat bacterial infected wound usually cannot reach high antibacterial ability and wound healing efficiency in the same time.This highlights the need to develop a dressing that can achieve both of these goals.Here,we developed a double-crosslinked hydrogel,loaded with phototriggered nitric oxide(NO)release ZIF-8 nanoparticles which combined photothermal effect in the same time,to synergistically treat bacterial infected wound.The released NO not only can enhance the antibacterial effect of hydrogel but also promote collagen deposition and angiogenesis in the same time,that accelerated would healing.Besides,the hydrogel can be extruded from syringe to fully cover irregular wound,and the mechanical strength of hydrogel was then strengthened by photo-crosslinking.Mechanical strength of the hydrogel remained stable after cyclic compression without cracking.In vitro experiments showed that the hydrogel possess certain swelling ratio and can be fully degraded within 14 days.This in-situ fast-curing hydrogel can heat up and release NO under the irradiation of 808 nm near infrared laser,and has a significant killing effect on Escherichia coli and Staphylococcus aureus.Compared with the commercial Aquacel Ag wound dressing,the hydrogel possessed higher healing rate.The highest level of vascularization on day7 was found in hydrogel treated group.The wound was completely healed after 14 days of hydrogel treatment,and the inflammation level was effectively controlled.Therefore,the NO released hydrogel working synergistically with photothermal therapy would be a promising way to treat bacterial infected wound. |
PDF Full Text Request