| Objective:To analyze the status of bone mineral density and its influencing factors i n some peri-menopausal women aged 40-60 years in Guiyang city,and the correlation between intra-abdominal fat,serum vitamin D and bone mineral density,so as to provide scientific basis for the prevention and treatment of osteoporosis in peri-menopausal women.Methods:The peri-menopausal women who were examined in the Health Management Center of the affiliated Hospital of Guizhou Medical University from June 2019 to November 2020 were selected as the subj ects,and the past medical history,lifestyle and eating habits were investiga ted by questionnaire,and the bone mineral density and intra-abdominal fat were measured by quantitative CT.At the same time,the serum vitamin D level was measured,and the bas ic characteristics,bone condition,vitamin D level and intra-abdominal fat an d the relationship among them were analyzed.Results:1.A total of 493 peri-menopausal women were included in this survey,with a minimum age of 40 years and a maximum age of 60 years,with an average age of 50.26 ±8.00 years.Among the women in this surve y,the comparison of age,place of residence,education level,family history of diabetes and fracture,seafood intake,vitamin D supplement,calcium supplement,exercise scene,exercise form,number of exercise times per week,time of each exercise,years of persistence,age of menarche,age of first birth,mode of production,the difference was statistically significant(P < 0.05).There was no significant difference in nationality,family history of osteoporosis,legume intake,smoking,passive smoking,drinking,dairy intake,sunshine time,exercise intensity and hormone use(P > 0.05).2.The number of people with osteoporosis,reduced bone mass and normal bone mass were 52(10.55%),121(24.54%)and 320(64.91%)respectively.There were significant differences in the distribution of bone status among people with different menstruation(P < 0.001).The detection rate of normal bone mass in the menopausal group(49.17 %)was lower than that in the non-menopausal group(80.08%).The number of people with vi tamin D deficiency,deficiency and normal were 185(37.53%),226(45.84%)and 82(16.63%),respectively.There were significant differences in the distribution of vitamin D among people with different menstruation(P < 0.001).The detection rate of vitamin D deficiency was higher in the premenopausal group(49.00%)and lower in the postmenopausal group(25.31%).3.There were significant differences in age,education le vel and family history of osteoporosis among different bone conditions(P < 0.05),but there was no significant difference in nationality,residence,family history of diabetes and family history of fracture(P > 0.05).In this survey,it was found that th ere were significant differences in exercise scene,weekly exercise times,each exercise time,menstruation and mode of production among women with different life styles(P < 0.05).4.By comparing the physiological and biochemical indexes of women with different menstrual status,it was found that there were significant differences in BMD,vi tamin D,total abdominal fat,visceral fat,SAT,height and BMI.In the comparison of different bone conditions,it was found that there were significant differences i n the mean levels of total abdominal fat,visceral fat,SAT,height and BMI.5.Low educa tion level(high school / higher vocational education)is the risk factor of abnormal bone mass(P < 0.05).6.Controlling age as a covariable,there was no linear correlation between vitamin D(r = 0.052),BMI(r = 0.060,P = 0.211),total fat(r = 0.088,P = 0.067),SAT(r = 0.062,P < 0.195)and BMD(P > 0.05).There was a weak negative correlation between visceral fat and BMD.There was no linear correlation between vitamin D,intra-abdominal fat,body mass index and BMD in women under different bone conditions by partial correlation analysis with age control as covariates.Conclusion1 the detection rate of osteoporosis and less bone mass in peri-menopausal women was lower than that in other areas.The detection rate of vitamin D deficiency and deficiency was similar to that in other areas.And the supplement rate of calcium tablets and vitamin D is low,sug gesting that osteoporosis and bone mass problems are prominent in peri-menopausal women,and the health screening and management of this period shou ld be strengthened.2 low education level(senior high school)and visceral fat area are the risk factors of abnormal bone mass in peri-menopausal women.There was no correlation between vitamin D,total abdominal fat,visceral fat and bone mineral density.This finding suggests that health education and health management of peri-menopausal women should be str engthened,and attention should be paid to their abdominal obesity,especially the distribution of body fat composition. |
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