The Effort Of Different SV On Conduit Patency Of The CABG

Background: The quality of the saphenous vein(SV)may vary with the harvest site.Currently,few studies have compared the performance of SV harvested from the thigh and calf as grafts in coronary artery bypass grafting(CABG)surgery.The one-year graft patency rates of SV grafts were collected from different portions of the lower limbs.The functional and structural viability of SV endothelium and smooth muscle cells were assessed.Methods: This observational r etrospective study comprised 265 patients who underwent CABG by the same surgical team between 201 6 and 2020.Each patient received one SV graft from the thigh and one from the calf,to the left or right coronary territory,to complement the left internal thoracic artery(LITA).One-year postoperative angiographic results of the SV grafts were compared.Surgical specimens were collected,starting from September 2018.Western blot and immunohistochemical analysis were performed to evaluate the expression,st ability,morphology,and localization of von Willebrand factor(v WF),matrix metalloproteinase-2(MMP-2),matrix metalloproteinase-9(MMP-9),vimentin,and caveolin-1(CAV-1).Results: Angiography at one-year demonstrated a higher patency rate of thigh SV grafts than calf SV grafts(95.4% versus 90.8%,P=0.058).The expression v WF,MMP-2,MMP-9,vimentin,and CAV-1 protein was significantly higher in calf SV grafts compared with thigh SV grafts(P ?0.05).Conclusions: The SV grafts from the thigh had higher p atency compared to those obtained from the calf,one year postoperatively.Comparing the functional and structural viability of SV endothelial and smooth muscl e cells,SV in the thigh were much better than that in the calf.Therefore,the thigh SV is a more appropriate conduit than the calf SV for coronary artery bypass grafting.